Three-month pegylated interferon-alpha-2a therapy for chronic hepatitis E virus infection in a haemodialysis patient

被引：85
作者：
Kamar, Nassim [1 ,2 ]
Abravanel, Florence [3 ,4 ]
Garrouste, Cyril [1 ,4 ]
Cardeau-Desangles, Isabelle [1 ]
Mansuy, Jean Michel [3 ]
Weclawiak, Hugo [1 ]
Izopet, Jacques [3 ,4 ]
Rostaing, Lionel [1 ,4 ]
机构：
[1] CHU Rangueil, Dept Nephrol Dialysis & Organ Transplantat, TSA 50032, F-31059 Toulouse 9, France
[2] CHU Rangueil, INSERM, U858, IFR BMT,TSA 50032, F-31059 Toulouse 9, France
[3] CHU Purpan, Dept Virol, TSA 40031, F-31059 Toulouse 9, France
[4] CHU Purpan, INSERM, U563, IFR BMT,TSA 40031, F-31059 Toulouse 9, France
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 2010年 / 25卷 / 08期
关键词：
chronic hepatitis; haemodialysis; hepatitis E virus; pegylated interferon; KIDNEY-TRANSPLANT; DIALYSIS PATIENTS; ALPHA; CIRRHOSIS; EFFICACY;
D O I：
10.1093/ndt/gfq282
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Hepatitis E virus (HEV) can induce chronic hepatitis in immunosuppressed patients. There is no established treatment for HEV infection. Pegylated interferon-alpha-2a (Peg-IFN-alpha-2a) has been successfully used for treating HEV infection in liver transplant patients with chronic hepatitis. A kidney transplant patient with chronic HEV infection evolved to end-stage kidney disease and started haemodialysis. Three months after immunosuppressive therapy was stopped, HEV RNA was still detected both in serum and in stools. Before considering a retransplantation, we decided to initiate Peg-IFN-alpha-2a therapy to eradicate the virus. A 3-month course of Peg-IFN-alpha-2a was scheduled, and the latter was started at the weekly dose [GRAPHICS] of 135 mu g. Serum HEV RNA became negative by Week 3 of Peg-IFN-alpha-2a therapy, and remained negative until the last follow-up, i.e. 6 months after anti-viral therapy was stopped. Hence, we report the first known case of a 3-month course of Peg-IFN-alpha-2a inducing a sustained virological response in this HEV-positive and RNA-positive haemodialysis patient who had failed to be cleared of the virus after immunosuppressant withdrawal.
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页码：2792 / 2795
页数：4
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