Three-month pegylated interferon-alpha-2a therapy for chronic hepatitis E virus infection in a haemodialysis patient

被引：84
作者：
Kamar, Nassim [1 ,2 ]
Abravanel, Florence [3 ,4 ]
Garrouste, Cyril [1 ,4 ]
Cardeau-Desangles, Isabelle [1 ]
Mansuy, Jean Michel [3 ]
Weclawiak, Hugo [1 ]
Izopet, Jacques [3 ,4 ]
Rostaing, Lionel [1 ,4 ]
机构：
[1] CHU Rangueil, Dept Nephrol Dialysis & Organ Transplantat, TSA 50032, F-31059 Toulouse 9, France
[2] CHU Rangueil, INSERM, U858, IFR BMT,TSA 50032, F-31059 Toulouse 9, France
[3] CHU Purpan, Dept Virol, TSA 40031, F-31059 Toulouse 9, France
[4] CHU Purpan, INSERM, U563, IFR BMT,TSA 40031, F-31059 Toulouse 9, France
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 2010年 / 25卷 / 08期
关键词：
chronic hepatitis; haemodialysis; hepatitis E virus; pegylated interferon; KIDNEY-TRANSPLANT; DIALYSIS PATIENTS; ALPHA; CIRRHOSIS; EFFICACY;
D O I：
10.1093/ndt/gfq282
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Hepatitis E virus (HEV) can induce chronic hepatitis in immunosuppressed patients. There is no established treatment for HEV infection. Pegylated interferon-alpha-2a (Peg-IFN-alpha-2a) has been successfully used for treating HEV infection in liver transplant patients with chronic hepatitis. A kidney transplant patient with chronic HEV infection evolved to end-stage kidney disease and started haemodialysis. Three months after immunosuppressive therapy was stopped, HEV RNA was still detected both in serum and in stools. Before considering a retransplantation, we decided to initiate Peg-IFN-alpha-2a therapy to eradicate the virus. A 3-month course of Peg-IFN-alpha-2a was scheduled, and the latter was started at the weekly dose [GRAPHICS] of 135 mu g. Serum HEV RNA became negative by Week 3 of Peg-IFN-alpha-2a therapy, and remained negative until the last follow-up, i.e. 6 months after anti-viral therapy was stopped. Hence, we report the first known case of a 3-month course of Peg-IFN-alpha-2a inducing a sustained virological response in this HEV-positive and RNA-positive haemodialysis patient who had failed to be cleared of the virus after immunosuppressant withdrawal.
引用
收藏
页码：2792 / 2795
页数：4
相关论文
共 19 条
  • [1] [Anonymous], 2008, Kidney Int Suppl, V109, pS1
  • [2] Efficacy and safety of pegylated-interferon α-2a in hemodialysis patients with chronic hepatitis C
    Ayaz, Celal
    Celen, Mustafa Kemal
    Yuce, Ugur Nedim
    Geyik, Mehmet Faruk
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (02) : 255 - 259
  • [3] An algorithm for the grading of activity in chronic hepatitis C
    Bedossa, P
    Poynard, T
    [J]. HEPATOLOGY, 1996, 24 (02) : 289 - 293
  • [4] Hepatitis E: an emerging infection in developed countries
    Dalton, Harry R.
    Bendall, Richard
    Ijaz, Samreen
    Banks, Malcolm
    [J]. LANCET INFECTIOUS DISEASES, 2008, 8 (11) : 698 - 709
  • [5] Persistent Carriage of Hepatitis E Virus in Patients with HIV Infection.
    Dalton, Harry R.
    Bendall, Richard P.
    Keane, Frances E.
    Tedder, Richard S.
    Ijaz, Samreen
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (10) : 1025 - 1027
  • [6] Chronic hepatitis E with cirrhosis in a kidney-transplant recipient
    Gerolami, Rene
    Moal, Valerie
    Colson, Philippe
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (08) : 859 - 860
  • [7] Chronic hepatitis E virus infection in liver transplant recipients
    Haagsma, Elizabeth B.
    van den Berg, Arie P.
    Porte, Robert J.
    Benne, Cornelis A.
    Vennema, Harry
    Reimerink, Johan H. J.
    Koopmans, Marion P. G.
    [J]. LIVER TRANSPLANTATION, 2008, 14 (04) : 547 - 553
  • [8] Hepatitis E virus-related cirrhosis in kidney- and kidney-pancreas-transplant recipients
    Kamar, N.
    Mansuy, J. -M.
    Cointault, O.
    Selves, J.
    Abravanel, F.
    Danjoux, M.
    Otal, R.
    Esposito, L.
    Durand, D.
    Izopet, J.
    Rostaing, L.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (08) : 1744 - 1748
  • [9] Evidence that clearance of hepatitis C virus RNA after α-interferon therapy in dialysis patients is sustained after renal transplantation
    Kamar, N
    Toupance, O
    Buchler, M
    Sandres-Saune, K
    Izopet, J
    Durand, D
    Rostaing, L
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (08): : 2092 - 2098
  • [10] Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
    Kamar, Nassim
    Selves, Janick
    Mansuy, Jean-Michel
    Ouezzani, Leila
    Peron, Jean-Marie
    Guitard, Joelle
    Cointault, Olivier
    Esposito, Laure
    Abravanel, Florence
    Danjoux, Marie
    Durand, Dominique
    Vinel, Jean-Pierre
    Izopet, Jacques
    Rostaing, Lionel
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (08) : 811 - 817
12