Direct Cross-Coupling of Allylic C(sp3)-H Bonds with Aryl- and Vinylbromides by Combined Nickel and Visible-Light Catalysis

被引：119

作者：

Huang, Long ^{[1
]}

Rueping, Magnus ^{[1
,2
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

[2] King Abdullah Univ Sci & Technol, KAUST Catalysis Ctr, Thuwal 239556900, Saudi Arabia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 32期

基金：

欧洲研究理事会;

关键词：

alkenes; allylic compounds; C-H activation; nickel; photocatalysis; PHOTOREDOX/NICKEL DUAL CATALYSIS; ROOM-TEMPERATURE; OXIDATIVE ADDITION; HALIDES; PALLADIUM; ACETATES; BROMIDES; DERIVATIVES; 9-MESITYL-10-METHYLACRIDINIUM; ARYLATION;

D O I：

10.1002/anie.201805118

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient protocol for the direct allylic C(sp(3))-H bond activation of unactivated tri- and tetrasubstituted alkenes and their functionalization with aryl- and vinylbromides by nickel and visible-light photocatalysis has been developed. The method allows C(sp(2))-C(sp(3)) formation under mild reaction conditions with good functional-group tolerance and excellent regioselectivity.

引用

页码：10333 / 10337

页数：5

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