Photoreactive threading agent that specifically binds to abasic sites in DNA

被引：14

作者：

Martelli, A

Jourdan, M

Constant, JF

Demeunynck, M

Dumy, P

机构：

[1] Univ Grenoble 1, LEDSS, UMR 5616, F-38041 Grenoble, France

[2] Univ Grenoble 1, ICMG, FR2607, F-38041 Grenoble, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 01期

关键词：

DNA binders; DNA photodamaging; acridine; NMR; abasic site;

D O I：

10.1016/j.bmcl.2005.09.026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the synthesis and study of a photoreactive nitrobenzamide containing acridine that specifically interacts at abasic site in DNA by threading intercalation and introduces under irradiation a lesion on the opposite strand at the unpaired pyrimidine. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：154 / 157

页数：4

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