NM 283, an efficient prodrug of the potent anti-HCV agent 2′-C-methylcytidine

被引：54

作者：

Pierra, C

Benzaria, S

Amador, A

Moussa, A

Mathieu, S

Storer, R

Gosselin, G

机构：

[1] Univ Montpellier 2, CNRS, Lab Cooperat Indenix, F-34095 Montpellier, France

[2] Lab Chim Med Indenix, Montpellier, France

[3] Idenix Pharmaceut Inc, Cambridge, MA USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2005年 / 24卷 / 5-7期

关键词：

hepatitis C virus; 2 '-C-methyl branched nucleosides; prodrugs;

D O I：

10.1081/NCN-200060112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to improve the oral bioavailability of 2'-C-methylcytidine, a potent anti-HCV agent, the corresponding 3'-O-L-valinyl ester derivative (NM 283) has been synthesized. Based on its ease Of synthesis and its physicochemical properties, NM 283 has emerged as a promising antiviral drug for treatment of chronic HCV infection.

引用

页码：767 / 770

页数：4

共 10 条

[1] ESTERIFICATION OF N-PROTECTED ALPHA-AMINO-ACIDS WITH ALCOHOL/CARBODIIMIDE/4-(DIMETHYLAMINO)-PYRIDINE - RACEMIZATION OF ASPARTIC AND GLUTAMIC-ACID DERIVATIVES [J].