Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH

被引：20

作者：

Welch, Ryan D. ^{[1
]}

Billon, Cyrielle ^{[2
,3
]}

Losby, McKenna ^{[4
]}

Bedia-Diaz, Gonzalo ^{[2
,3
]}

Fang, Yuanying ^{[2
,3
]}

Avdagic, Amer ^{[2
,3
]}

Elgendy, Bahaa ^{[2
,3
,5
]}

Burris, Thomas P. ^{[6
]}

Griffett, Kristine ^{[7
]}

机构：

[1] Blackburn Coll, Biol & Chem Dept, Carlinville, IL 62626 USA

[2] Univ Hlth Sci & Pharm, Ctr Clin Pharmacol, St Louis, MO 63110 USA

[3] Washington Univ, St Louis, MO 63110 USA

[4] Washington Univ, Biochem Biophys & Struct Biol, Sch Med, St Louis, MO 63110 USA

[5] Washington Univ, Dept Anesthesiol, Sch Med, St Louis, MO 63110 USA

[6] Univ Florida, UF Genet Inst, Gainesville, FL 32611 USA

[7] Auburn Univ, Coll Vet Med, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA

来源：

METABOLITES | 2022年 / 12卷 / 03期

关键词：

non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; nuclear receptors; lipogenesis; metabolism; inflammation; glucose metabolism; oxidative stress; insulin sensitivity; fibrosis; therapeutics; LIVER-X-RECEPTOR; REV-ERB-ALPHA; NLRP3 INFLAMMASOME ACTIVATION; LXR INVERSE AGONIST; BILE-ACID SYNTHESIS; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS; LIPID-METABOLISM; HEPATIC STEATOSIS; GENE-EXPRESSION;

D O I：

10.3390/metabo12030238

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-alcoholic fatty liver (NAFLD) over the past years has become a metabolic pandemic linked to a collection of metabolic diseases. The nuclear receptors ERRs, REV-ERBs, RORs, FXR, PPARs, and LXR are master regulators of metabolism and liver physiology. The characterization of these nuclear receptors and their biology has promoted the development of synthetic ligands. The possibility of targeting these receptors to treat NAFLD is promising, as several compounds including Cilofexor, thiazolidinediones, and Saroglitazar are currently undergoing clinical trials. This review focuses on the latest development of the pharmacology of these metabolic nuclear receptors and how they may be utilized to treat NAFLD and subsequent comorbidities.

引用

页数：28

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