Receptor Dynamics in Signaling

被引：4

作者：

Becker, Verena ^{[1
,2
]}

Timmer, Jens ^{[3
]}

Klingmueller, Ursula ^{[2
,4
]}

机构：

[1] German Canc Res Ctr, Div Syst Biol Signal Transduct, DKFZ ZMBH Alliance, D-6900 Heidelberg, Germany

[2] Heidelberg Univ, Bioquant, D-6900 Heidelberg, Germany

[3] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, Freiburg Inst Adv Studies, Inst Phys,Ctr Syst Biol, D-79106 Freiburg, Germany

[4] German Canc Res Ctr, DKFZ ZMBH Alliance, Div Syst Biol Signal Transduct, D-6900 Heidelberg, Germany

来源：

ADVANCES IN SYSTEMS BIOLOGY | 2012年 / 736卷

关键词：

EPIDERMAL-GROWTH-FACTOR; ERYTHROPOIETIN RECEPTOR; SYSTEMS BIOLOGY; DOWN-REGULATION; ENDOPLASMIC-RETICULUM; TRANSMEMBRANE DOMAIN; ACTIVATING MUTATION; KINASE INHIBITORS; DRUG DISCOVERY; C-MET;

D O I：

10.1007/978-1-4419-7210-1_18

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Reliable inter- and intracellular communication is central to both the development and the integrity of multicellular organisms. Key mediators of these processes are cell surface receptors that perceive and convert extracellular cues to trigger intracellular signaling networks and ultimately a phenotypic response. Deregulation of signal transduction leads to a variety of diseases, and aberrations in receptor proteins are very common in various cancer types. Therefore, cell surface receptors have been established as major targets in drug discovery. However, in order to efficiently apply therapeutics, it is crucial to gain knowledge about design principles of receptor signaling. In this chapter, we will discuss signal transduction at the receptor level for examples from different receptor classes.

引用

页码：313 / 323

页数：11

共 61 条

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