Kinase Inhibitors from Marine Sponges

被引：58
作者：
Skropeta, Danielle [1 ,2 ]
Pastro, Natalie [1 ]
Zivanovic, Ana [1 ]
机构：
[1] Univ Wollongong, Sch Chem, Wollongong, NSW 2522, Australia
[2] Univ Wollongong, Ctr Med Chem, Wollongong, NSW 2522, Australia
来源：
MARINE DRUGS | 2011年 / 9卷 / 10期
关键词：
marine sponges; marine natural products; protein kinase inhibitors; cell regulation; anticancer agents; CYCLIN-DEPENDENT KINASES; HUMAN-BREAST-CANCER; AMINO-ACID RESIDUE; SESQUITERPENOID QUINONES; NATURAL-PRODUCTS; BROMOPYRROLE ALKALOIDS; STRUCTURE ELUCIDATION; XESTOCYCLAMINE-A; C INHIBITOR; ONNAMIDE-A;
D O I：
10.3390/md9102131
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.
引用
收藏
页码：2131 / 2154
页数：24
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