Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia

被引：2

作者：

Guo, Qinhua ^{[1
]}

Lan, Jin ^{[1
]}

Zhang, Weiqiao ^{[1
]}

Guo, Pin ^{[1
]}

Guo, Liemei ^{[1
]}

Li, Zhiqiang ^{[2
]}

Qiu, Yongming ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Neurosurg, Shanghai 200127, Peoples R China

[2] Anhui Univ Sci & Technol, Shanghai Neurol Res Inst, Cent Hosp Fengxian Dist, Shanghai 201400, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 02期

基金：

中国国家自然科学基金;

关键词：

apoptosis; excitatory amino acid carrier 1; global cerebral ischemia; glutamate-aspartate transporter; glutamate transporter; glutamate transporter-1; neuroprotection; GLT-1; RELEASE; INJURY;

D O I：

10.3969/j.issn.1673-5374.2012.02.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The present study established a rat model of global cerebral ischemia induced by chest compression for six minutes to dynamically observe expressional changes of three glutamate transporters in the cerebral cortex and hippocampus. After 24 hours of ischemia, expression of glutamate transporter-1 significantly decreased in the cerebral cortex and hippocampus, which was accompanied by neuronal necrosis. At 7 days post-ischemia, expression of excitatory amino acid carrier 1 decreased in the hippocampal CA1 region and cortex, and was accompanied by apoptosis. Expression of glutamate-aspartate transporter remained unchanged at 6 hours-7 days after ischemia. These results suggested that glutamate transporter levels were altered at different periods of cerebral ischemia.

引用

页码：125 / 130

页数：6

共 50 条

[1] Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia
Qinhua Guo1
NeuralRegenerationResearch, 2012, 7 (02) : 125 - 130
[2] The expression of glutamate transporters in chest compression-induced audiogenic epilepsy: a comparative study
Lu, Zhaofeng
Zhang, Weiqiao
Zhang, Ning
Jiang, Jiyao
Luo, Qizhong
Qiu, Yongming
NEUROLOGICAL RESEARCH, 2008, 30 (09) : 915 - 919
[3] CHANGES IN VESICULAR GLUTAMATE TRANSPORTERS IN A MURINE MODEL OF GLOBAL CEREBRAL ISCHEMIA
Khan, Sabah
Yuldasheva, Nadira
Saha, Sikha
HEART, 2016, 102 : A12 - A13
[4] Immunocytochemical localization of candidates for vesicular glutamate transporters in the rat cerebral cortex
Fujiyama, F
Furuta, T
Kaneko, T
JOURNAL OF COMPARATIVE NEUROLOGY, 2001, 435 (03) : 379 - 387
[5] Agmatine reduces nitric oxide synthase expression and peroxynitrite formation in the cerebral cortex in a rat model of transient global cerebral ischemia
Mun, Chin Hee
Lee, Won Taek
Park, Kyung Ah
Lee, Jong Eun
NEURAL REGENERATION RESEARCH, 2010, 5 (23) : 1773 - 1781
[6] Agmatine reduces nitric oxide synthase expression and peroxynitrite formation in the cerebral cortex in a rat model of transient global cerebral ischemia
Chin Hee Mun
Won Taek Lee
Kyung Ah Park
Jong Eun Lee
Neural Regeneration Research, 2010, 5 (23) : 1773 - 1781
[7] Pharmacology of ischemia-induced glutamate efflux from rat cerebral cortex in vitro
Nelson, RM
Lambert, DG
Green, AR
Hainsworth, AH
BRAIN RESEARCH, 2003, 964 (01) : 1 - 8
[8] Hippocampal Neurogenesis in the New Model of Global Cerebral Ischemia
Kisel, A. A.
Chernysheva, G. A.
Smol'yakova, V. I.
Savchenko, R. R.
Plotnikov, M. B.
Khodanovich, M. Yu
NEW OPERATIONAL TECHNOLOGIES (NEWOT'2015), 2015, 1688
[9] Microarray analysis of hippocampal gene expression in global cerebral ischemia
Jin, KL
Mao, XO
Eshoo, MW
Nagayama, T
Minami, M
Simon, RP
Greenberg, DA
ANNALS OF NEUROLOGY, 2001, 50 (01) : 93 - 103
[10] Differential expression of glutamate transporters in cerebral cortex of paraoxon-treated rats
Zare, Zohreh
Tehrani, Mohsen
Rafiei, Alireza
Valadan, Reza
Mohammadi, Moslem
NEUROTOXICOLOGY AND TERATOLOGY, 2017, 62 : 20 - 26

← 1 2 3 4 5 →