Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus

被引：82
作者：
Malaguarnera, M
DiFazio, I
Romeo, MA
Restuccia, S
Laurino, A
Trovato, BA
机构：
[1] Dept. of Int. Med. and Geriatrics, University of Catania, 829-95126 Catania, P.O. Cannizzaro via Messina
来源：
JOURNAL OF GASTROENTEROLOGY | 1997年 / 32卷 / 02期
关键词：
cytokines; interleukin 6 (IL-6); hepatitis C virus (HCV); chronic hepatitis; histological activity index (HAI);
D O I：
10.1007/BF02936370
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Interleukin 6 (IL-6) is a pleiotropic cytokine produced by a wide variety of lymphoid and nonlymphoid tissues. We studied the relationship between IL-6 and the liver in an attempt to elucidate this cytokine's role in hepatitis C-induced liver inflammation. We investigated the behavior of serum IL-6 in 25 patients with chronic hepatitis C (divided into three groups depending on severity) and in 27 healthy controls. Our results showed a significant elevation (P < 0.0001) in serum IL-6 levels in the patients with chronic hepatitis C, correlated with the histological activity index (HAI) and their HCV-RNA serum levels. This rise may represent the expression of the hepatitis C virus-induced inflammatory state.
引用
收藏
页码：211 / 215
页数：5
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