Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation

被引：40

作者：

Cautivo, Kelly M. ^{[1
]}

Matatia, Peri R. ^{[1
]}

Lizama, Carlos O. ^{[2
]}

Mroz, Nicholas M. ^{[1
,4
]}

Dahlgren, Madelene W. ^{[1
]}

Yu, Xiaofei ^{[1
]}

Sbierski-Kind, Julia ^{[1
]}

Taruselli, Marcela T. ^{[1
]}

Brooks, Jeremy F. ^{[5
]}

Wade-Vallance, Adam ^{[4
]}

Caryotakis, Sofia E. ^{[4
]}

Chang, Anthony A. ^{[1
,4
]}

Liang, Hong-Erh ^{[5
,6
]}

Zikherman, Julie ^{[5
]}

Locksley, Richard M. ^{[5
,6
]}

Molofsky, Ari B. ^{[1
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA USA

[3] Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Biomed Sci Grad Program, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA USA

来源：

IMMUNITY | 2022年 / 55卷 / 02期

关键词：

IFN-GAMMA; RESIDENT MEMORY; T-CELLS; LISTERIA-MONOCYTOGENES; TISSUE-REPAIR; INNATE; MICE; RECEPTOR; RESPONSES; LUNG;

D O I：

10.1016/j.immuni.2021.12.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial-and microbial-rich barriers. However, ILC2s and Th2 cells are also present in fibroblast-rich niches within the adventitial layer of larger vessels and similar boundary structures in sterile deep tissues, and it remains unclear whether they undergo dynamic repositioning during immune perturbations. Here, we used thick-section quantitative imaging to show that allergic inflammation drives invasion of lung and liver non-adventitial parenchyma by ILC2s and Th2 cells. However, during concurrent type 1 and type 2 mixed inflammation, IFNg from broadly distributed type 1 lymphocytes directly blocked both ILC2 parenchymal trafficking and subsequent cell survival. ILC2 and Th2 cell confinement to adventitia limited mortality by the type 1 pathogen Listeria monocytogenes. Our results suggest that the topography of tissue lymphocyte subsets is tightly regulated to promote appropriately timed and balanced immunity.

引用

页码：254 / +

页数：26

共 92 条

[11] Atopic dermatitis: The role of recombinant interferon-γ therapy [J].

Chang T.T. ;

Stevens S.R. .

American Journal of Clinical Dermatology, 2002, 3 (3) :175-183

[12] Why is Listeria monocytogenes such a potent inducer of CD8+T-cells? [J].

Chavez-Arroyo, Alfredo ;

Portnoy, Daniel A. .

CELLULAR MICROBIOLOGY, 2020, 22 (04)

[13] Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity [J].

Colonna, Marco .

IMMUNITY, 2018, 48 (06) :1104-1117

[14] TSLP: from allergy to cancer [J].

Corren, Jonathan ;

Ziegler, Steven F. .

NATURE IMMUNOLOGY, 2019, 20 (12) :1603-1609

[15]

Coyle AJ, 1996, J IMMUNOL, V156, P2680

[16] Adventitial Cuffs: Regional Hubs for Tissue Immunity [J].

Dahlgren, Madelene W. ;

Molofsky, Ari B. .

TRENDS IN IMMUNOLOGY, 2019, 40 (10) :877-887

[17] Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches [J].

Dahlgren, Madelene W. ;

Jones, Stephen W. ;

Cautivo, Kelly M. ;

Dubinin, Alexandra ;

Ortiz-Carpena, Jorge F. ;

Farhat, Sepideh ;

Yu, Kevin S. ;

Lee, Katharine ;

Wang, Chaoqun ;

Molofsky, Anna, V ;

Tward, Aaron D. ;

Krummel, Matthew F. ;

Peng, Tien ;

Molofsky, Ari B. .

IMMUNITY, 2019, 50 (03) :707-+

[18] All along the watchtower: group 2 innate lymphoid cells in allergic responses [J].

Dahlgren, Madelene W. ;

Molofsky, Ari B. .

CURRENT OPINION IN IMMUNOLOGY, 2018, 54 :13-19

[19] Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells [J].

Duerr, Claudia U. ;

McCarthy, Connor D. A. ;

Mindt, Barbara C. ;

Rubio, Manuel ;

Meli, Alexandre P. ;

Pothlichet, Julien ;

Eva, Megan M. ;

Gauchat, Jean-Francois ;

Qureshi, Salman T. ;

Mazer, Bruce D. ;

Mossman, Karen L. ;

Malo, Danielle ;

Gamero, Ana M. ;

Vidal, Silvia M. ;

King, Irah L. ;

Sarfati, Marika ;

Fritz, Joerg H. .

NATURE IMMUNOLOGY, 2016, 17 (01) :65-+

[20] Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations [J].

Dutton, Emma E. ;

Gajdasik, Dominika W. ;

Willis, Claire ;

Fiancette, Remi ;

Bishop, Emma L. ;

Camelo, Ana ;

Sleeman, Matthew A. ;

Coccia, Margherita ;

Didierlaurent, Arnaud M. ;

Tomura, Michio ;

Pilataxi, Fernanda ;

Morehouse, Christopher A. ;

Carlesso, Gianluca ;

Withers, David R. .

SCIENCE IMMUNOLOGY, 2019, 4 (35)

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