Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation

被引：38

作者：

Cautivo, Kelly M. ^{[1
]}

Matatia, Peri R. ^{[1
]}

Lizama, Carlos O. ^{[2
]}

Mroz, Nicholas M. ^{[1
,4
]}

Dahlgren, Madelene W. ^{[1
]}

Yu, Xiaofei ^{[1
]}

Sbierski-Kind, Julia ^{[1
]}

Taruselli, Marcela T. ^{[1
]}

Brooks, Jeremy F. ^{[5
]}

Wade-Vallance, Adam ^{[4
]}

Caryotakis, Sofia E. ^{[4
]}

Chang, Anthony A. ^{[1
,4
]}

Liang, Hong-Erh ^{[5
,6
]}

Zikherman, Julie ^{[5
]}

Locksley, Richard M. ^{[5
,6
]}

Molofsky, Ari B. ^{[1
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA USA

[3] Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Biomed Sci Grad Program, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA USA

来源：

IMMUNITY | 2022年 / 55卷 / 02期

关键词：

IFN-GAMMA; RESIDENT MEMORY; T-CELLS; LISTERIA-MONOCYTOGENES; TISSUE-REPAIR; INNATE; MICE; RECEPTOR; RESPONSES; LUNG;

D O I：

10.1016/j.immuni.2021.12.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial-and microbial-rich barriers. However, ILC2s and Th2 cells are also present in fibroblast-rich niches within the adventitial layer of larger vessels and similar boundary structures in sterile deep tissues, and it remains unclear whether they undergo dynamic repositioning during immune perturbations. Here, we used thick-section quantitative imaging to show that allergic inflammation drives invasion of lung and liver non-adventitial parenchyma by ILC2s and Th2 cells. However, during concurrent type 1 and type 2 mixed inflammation, IFNg from broadly distributed type 1 lymphocytes directly blocked both ILC2 parenchymal trafficking and subsequent cell survival. ILC2 and Th2 cell confinement to adventitia limited mortality by the type 1 pathogen Listeria monocytogenes. Our results suggest that the topography of tissue lymphocyte subsets is tightly regulated to promote appropriately timed and balanced immunity.

引用

页码：254 / +

页数：26

共 92 条

[1] Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin [J].

Allen, Judith E. ;

Sutherland, Tara E. .

SEMINARS IN IMMUNOLOGY, 2014, 26 (04) :329-340

[2] Intravascular staining for discrimination of vascular and tissue leukocytes [J].

Anderson, Kristin G. ;

Mayer-Barber, Katrin ;

Sung, Heungsup ;

Beura, Lalit ;

James, Britnie R. ;

Taylor, Justin J. ;

Qunaj, Lindor ;

Griffith, Thomas S. ;

Vezys, Vaiva ;

Barber, Daniel L. ;

Masopust, David .

NATURE PROTOCOLS, 2014, 9 (01) :209-222

[3] Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory [J].

Beura, Lalit K. ;

Mitchell, Jason S. ;

Thompson, Emily A. ;

Schenkel, Jason M. ;

Mohammed, Javed ;

Wijeyesinghe, Sathi ;

Fonseca, Raissa ;

Burbach, Brandon J. ;

Hickman, Heather D. ;

Vezys, Vaiva ;

Fife, Brian T. ;

Masopust, David .

NATURE IMMUNOLOGY, 2018, 19 (02) :173-+

[4] Cross-tissue organization of the fibroblast lineage [J].

Buechler, Matthew B. ;

Pradhan, Rachana N. ;

Krishnamurty, Akshay T. ;

Cox, Christian ;

Calviello, Aslihan Karabacak ;

Wang, Amber W. ;

Yang, Yeqing Angela ;

Tam, Lucinda ;

Caothien, Roger ;

Roose-Girma, Merone ;

Modrusan, Zora ;

Arron, Joseph R. ;

Bourgon, Richard ;

Muller, Soren ;

Turley, Shannon. J. .

NATURE, 2021, 593 (7860) :575-+

[5] Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury [J].

Cameron, Guy J. M. ;

Cautivo, Kelly M. ;

Loering, Svenja ;

Jiang, Simon H. ;

Deshpande, Aniruddh V. ;

Foster, Paul S. ;

McKenzie, Andrew N. J. ;

Molofsky, Ari B. ;

Hansbro, Philip M. ;

Starkey, Malcolm R. .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[6] ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites [J].

Campbell, Laura ;

Hepworth, Matthew R. ;

Whittingham-Dowd, Jayde ;

Thompson, Seona ;

Bancroft, Allison J. ;

Hayes, Kelly S. ;

Shaw, Tovah N. ;

Dickey, Burton F. ;

Flamar, Anne-Laure ;

Artis, David ;

Schwartz, David A. ;

Evans, Christopher M. ;

Roberts, Ian S. ;

Thornton, David J. ;

Grencis, Richard K. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2019, 216 (12) :2714-2723

[7] Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion [J].

Castro, Flavia ;

Cardoso, Ana Patricia ;

Goncalves, Raquel Madeira ;

Serre, Karine ;

Oliveira, Maria Jose .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[8] Immune outposts in the adventitia: One foot in sea and one on shore [J].

Cautivo, Kelly M. ;

Steer, Catherine A. ;

Molofsky, Ari B. .

CURRENT OPINION IN IMMUNOLOGY, 2020, 64 :34-41

[9] AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue [J].

Cautivo, Kelly M. ;

Lizama, Carlos O. ;

Tapia, Pablo J. ;

Agarwal, Anil K. ;

Garg, Abhimanyu ;

Horton, Jay D. ;

Cortes, Vctor A. .

MOLECULAR METABOLISM, 2016, 5 (07) :491-505

[10] Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells [J].

Cautivo, Kelly M. ;

Molofsky, Ari B. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 (06) :1315-1325

← 1 2 3 4 5 6 7 8 9 10 →