Fluorescence-based implantable biosensors:: Monte Carlo modeling for optical probe design

被引：0

作者：

McShane, M ^{[1
]}

Rastegar, S ^{[1
]}

Coté, G ^{[1
]}

机构：

[1] Texas A&M Univ, Biomed Engn Program, College Stn, TX 77843 USA

来源：

PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6: BIOMEDICAL ENGINEERING TOWARDS THE YEAR 2000 AND BEYOND | 1998年 / 20卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Implantable fluorescent sensors may be an attractive solution to the monitoring of many parameters of biomedical interest. A Monte Carlo simulation of photon propagation through human shin and interaction with a subcutaneous fluorescent sensing layer is presented. Results me analyzed with respect to output light intensity as a function of distance from source, input-to-output characteristics; and single-photon versus dual-photon excitation The results indicate that radial fluorescence emission profile is broad compared to the diffusely reflected input Light. Response intensity has an approximately logarithmic relationship with sensor thickness. Estimated values for tissue autofluorescence quantum yield lead to an approximately Inverse relationship between sensor signal-to-noise ratio. One-photon excitation exhibits higher per-photon yield than two-photon excitation.

引用

页码：1799 / 1802

页数：4

共 50 条

[41] Monte-Carlo-Based Impulse Response Modeling for Underwater Wireless Optical Communication [J].

Dong, Feibiao ;

Xu, Limei ;

Jiang, Dagang ;

Zhang, Tianhong .

PROGRESS IN ELECTROMAGNETICS RESEARCH M, 2017, 54 :137-144

[42] Monte Carlo modeling and phantom study for implantable fluorescent analyte sensors for human head [J].

Wan, Qiujie ;

Beier, Hope T. ;

Ibey, Bennett L. ;

Good, Theresa ;

Cot, Gerard L. .

OPTICAL DIAGNOSTICS AND SENSING VII, 2007, 6445

[43] Enhancement of fluorescence-based sensing using microstructured optical fibres [J].

Afshar V., Shahraam ;

Warren-Smith, Stephen C. ;

Monro, Tanya M. .

OPTICS EXPRESS, 2007, 15 (26) :17891-17901

[44] Polydopamine as a versatile optical indicator for colorimetric and fluorescence-based biosensing [J].

Sulipta, Jena Subhra ;

Jeong, Haejin ;

Hong, Seonki .

BIOMATERIALS SCIENCE, 2025, 13 (09) :2261-2273

[45] Quasidistributed fluorescence-based optical fiber temperature sensor system [J].

Sun, T ;

Zhang, ZY ;

Grattan, KTV ;

Palmer, AW .

REVIEW OF SCIENTIFIC INSTRUMENTS, 1998, 69 (01) :146-151

[46] MONTE-CARLO MODELING OF SECONDARY X-RAY-FLUORESCENCE ACROSS PHASE BOUNDARIES IN ELECTRON-PROBE MICROANALYSIS [J].

MYKLEBUST, RL ;

NEWBURY, DE .

SCANNING, 1995, 17 (04) :235-242

[47] Optimal design of a fluorescence oxygen sensing probe based on multimode optical fibers [J].

Yingxin Zeng ;

Zhe Chen ;

Rongsheng Chen ;

Yanbiao Liao ;

Jianbin Liu ;

Huihui Lu ;

Xingdan Chen .

Optical and Quantum Electronics, 2015, 47 :2371-2379

[48] Optimal design of a fluorescence oxygen sensing probe based on multimode optical fibers [J].

Zeng, Yingxin ;

Chen, Zhe ;

Chen, Rongsheng ;

Liao, Yanbiao ;

Liu, Jianbin ;

Lu, Huihui ;

Chen, Xingdan .

OPTICAL AND QUANTUM ELECTRONICS, 2015, 47 (07) :2371-2379

[49] Modeling and simulations of the pharmacokinetics of fluorophore conjugated antibodies in tumor vicinity for the optimization of fluorescence-based optical imaging [J].

Fibich, G ;

Hammer, A ;

Gannot, G ;

Gandjbakhche, A ;

Gannot, I .

LASERS IN SURGERY AND MEDICINE, 2005, 37 (02) :155-160

[50] Progress toward implantable fluorescence-based sensors for monitoring glucose levels in interstitial fluid [J].

McShane, MJ ;

O'Neal, DP ;

Russell, RJ ;

Pishko, MV ;

Coté, GL .

OPTICAL DIAGNOSTICS OF BIOLOGICAL FLUIDS V, 2000, 3923 :78-87

← 1 2 3 4 5 →