CsrA and TnaB Coregulate Tryptophanase Activity To Promote Exotoxin-Induced Killing of Caenorhabditis elegans by Enteropathogenic Escherichia coli

被引：21
作者：
Bhatt, Shantanu [1 ,2 ]
Anyanful, Akwasi [1 ]
Kalman, Daniel [1 ,2 ]
机构：
[1] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
[2] Emory Univ, Microbiol & Mol Genet Program, Atlanta, GA 30322 USA
来源：
JOURNAL OF BACTERIOLOGY | 2011年 / 193卷 / 17期
基金：
美国国家科学基金会;
关键词：
BINDING PROTEIN CSRA; TYROSINE PHENOL-LYASE; MURINE COLONIC HYPERPLASIA; FORM ACTIN PEDESTALS; III SECRETION SYSTEM; PSEUDOMONAS-AERUGINOSA; CITROBACTER-FREUNDII; OPERON EXPRESSION; VIRULENCE FACTORS; POLYSACCHARIDE ADHESIN;
D O I：
10.1128/JB.05197-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Enteropathogenic Escherichia coli (EPEC) requires the tnaA-encoded enzyme tryptophanase and its substrate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabditis elegans. Here, we demonstrate that the RNA-binding protein CsrA and the tryptophan permease TnaB coregulate tryptophanase activity, through mutually exclusive pathways, to stimulate toxin-mediated paralysis and killing of C. elegans.
引用
收藏
页码：4516 / 4522
页数：7
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