Zn(II) dipicolylamine-based artificial receptor as a new entry for surface recognition of α-helical peptides in aqueous solution

被引：31
作者：
Mito-Oka, Y
Tsukiji, S
Hiraoka, T
Kasagi, N
Shinkai, S
Hamachi, I [1 ]
机构：
[1] Kyushu Univ, Grad Sch Engn, Dept Chem & Biochem, Fukuoka 8128581, Japan
[2] JST, PRESTO, Tokyo, Japan
[3] Inst Mol Sci, Okazaki, Aichi 4448585, Japan
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 40期
关键词：
peptide recognition; artificial receptor; Zn(II) dipicolylamine complex;
D O I：
10.1016/S0040-4039(01)01408-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
It is clear by CD spectral titration that Zn(II)dipicolylamine-based dinuclear complexes selectively bind and stabilize the alpha -helix conformation of peptides having two histidine (His) residues at specific positions (H-i and i+4 or i+7 or i+11). (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7059 / 7062
页数：4
相关论文
共 15 条
[1]   MOLECULAR RECOGNITION OF PROTEINS - SEQUENCE-SELECTIVE BINDING OF ASPARTATE PAIRS IN HELICAL PEPTIDES [J].
ALBERT, JS ;
GOODMAN, MS ;
HAMILTON, AD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (03) :1143-1144
[2]   Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice [J].
Blaskovich, MA ;
Lin, Q ;
Delarue, FL ;
Sun, J ;
Park, HS ;
Coppola, D ;
Hamilton, AD ;
Sebti, SM .
NATURE BIOTECHNOLOGY, 2000, 18 (10) :1065-1070
[3]   Sequence selective binding of peptides by artificial receptors in aqueous solution [J].
Breslow, R ;
Yang, ZW ;
Ching, R ;
Trojandt, G ;
Odobel, F .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (14) :3536-3537
[4]   SECONDARY STRUCTURE NUCLEATION IN PEPTIDES - TRANSITION-METAL ION STABILIZED ALPHA-HELICES [J].
GHADIRI, MR ;
CHOI, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (04) :1630-1632
[5]  
Hamachi H, 2000, BIOPOLYMERS, V55, P459, DOI 10.1002/1097-0282(2000)55:6<459::AID-BIP1021>3.0.CO
[6]  
2-R
[7]   Guest-induced umpolung on a protein surface: A strategy for regulation of enzymatic activity [J].
Hamachi, I ;
Eboshi, R ;
Watanabe, J ;
Shinkai, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (18) :4530-4531
[8]   Pd(en) as a sequence-selective molecular pinch for α-helical peptides [J].
Hamachi, I ;
Kasagi, N ;
Kiyonaka, S ;
Nagase, T ;
Mito-oka, Y ;
Shinkai, S .
CHEMISTRY LETTERS, 2001, (01) :16-17
[9]   A calixarene with four peptide loops: An antibody mimic for recognition of protein surfaces [J].
Hamuro, Y ;
Calama, MC ;
Park, HS ;
Hamilton, AD .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1997, 36 (23) :2680-2683
[10]   RATE AND EQUILIBRIUM DATA FOR SUBSTITUTION-REACTIONS OF DIAQUA(ETHYLENEDIAMINE)PALLADIUM(II) WITH CHLORIDE IN AQUEOUS-SOLUTION [J].
HOHMANN, H ;
VANELDIK, R .
INORGANICA CHIMICA ACTA, 1990, 174 (01) :87-92
12