Gemcitabine Delivery and Photodynamic Therapy in Cancer Cells via Porphyrin-Ethylene-Based Periodic Mesoporous Organosilica Nanoparticles

被引：34

作者：

Aggad, Dina ^{[1
]}

Jimenez, Chiara Mauriello ^{[2
]}

Dib, Soraya ^{[2
]}

Croissant, Jonas G. ^{[3
]}

Lichon, Laure ^{[1
]}

Laurencin, Danielle ^{[2
]}

Richeter, Sebastien ^{[2
]}

Maynadier, Marie ^{[4
]}

Alsaiari, Shahad K. ^{[3
]}

Boufatit, Makhlouf ^{[5
]}

Raehm, Laurence ^{[2
]}

Garcia, Marcel ^{[1
]}

Khashab, Niveen M. ^{[3
]}

Gary-Bobo, Magali ^{[1
]}

Durand, Jean-Olivier ^{[2
]}

机构：

[1] UM Fac Pharm, Inst Biomol Max Mousseron, CNRS, UMR 5247, Ave Charles Flahault, F-34093 Montpellier 05, France

[2] Inst Charles Gerhardt Montpellier, CNRS, UM ENSCM Cc 1701, UMR 5253, Pl Eugene Bataillon, F-34095 Montpellier 05, France

[3] King Abdullah Univ Sci & Technol, Adv Membranes & Porous Mat Ctr, Smart Hybrid Mat Lab, Thuwal, Saudi Arabia

[4] NanoMedSyn, Ave Charles Flahault, F-34093 Montpellier 05, France

[5] USTHB, Fac Chim, Lab Electrochim Corros Met & Chim Minerale, BP 32, Bab Ezzouar 16111, Alger, Algeria

来源：

CHEMNANOMAT | 2018年 / 4卷 / 01期

关键词：

gemcitabine; mesoporous organosilica nanoparticles; photodynamic therapy; porphyrin; two-photon; HUMAN PANCREATIC-CANCER; SILICA NANOPARTICLES; DRUG-DELIVERY; IN-VITRO; NANORODS; NANOSPHERES; ENHANCEMENT; RESISTANCE; CHEMISTRY; EMISSION;

D O I：

10.1002/cnma.201700264

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gemcitabine hydrochloride is an FDA-approved chemotherapeutic drug used in the treatment of various cancers. Several drawbacks of gemcitabine, including its short in vivo half-life of 8-17min associated with a rapid excretion by the kidneys and its poor membrane permeability, have inspired research on a nanodelivery approach. In this study, we report ethylene-based periodic mesoporous organosilica nanoparticles (PMOs) for photodynamic therapy and the autonomous delivery of gemcitabine in cancer cells. Porphyrins were used as photosensitizers and were localized in the walls of the PMOs while a high loading capacity of gemcitabine was observed in the porous structure. Depending on the nature of the photosensitizer, and its aggregation state, we were able to perform one or two-photon photodynamic therapy. Two-photon excited photodynamic therapy combined with gemcitabine delivery led to a synergy and a very efficient cancer cell killing.

引用

页码：46 / 51

页数：6

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