Comparison of Antiobesity Effects Between Gochujangs Produced Using Different Koji Products and Tabasco Hot Sauce in Rats Fed a High-Fat Diet

被引:8
作者
Son, Hee-Kyoung [1 ]
Shin, Hye-Won [2 ]
Jang, Eun-Seok [2 ]
Moon, Byoung-Seok [2 ]
Lee, Choong-Hwan [3 ]
Lee, Jae-Joon [1 ]
机构
[1] Chosun Univ, Dept Food & Nutr, 309 Pilmun Daero, Gwangju 61452, South Korea
[2] CJ CheilJedang Corp, Foods Res Inst, Suwon, South Korea
[3] Konkuk Univ, Dept Biosci & Biotechnol, Seoul, South Korea
关键词
antiobesity; gochujang; high-fat diet; koji; metabolite; Tabasco hot sauce; RICE KOJI; BODY-WEIGHT; CAPSAICIN; CHOLESTEROL; HOMEOSTASIS; EXPRESSION; STEATOSIS; INSULIN; QUALITY; OBESITY;
D O I
10.1089/jmf.2017.4007
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
In this study, we compared the antiobesity effects between gochujangs prepared using different koji products and Tabasco hot sauce in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were fed HFD containing four different types of 10% gochujang powder or 0.25% commercial Tabasco sauce powder for 8 weeks. The body weight gain, liver and epididymal and mesenteric fat pad weights, serum leptin levels, and lipogenesis-related mRNA levels of HFD-gochujang supplementation groups were significantly decreased compared with those of the HFD group. In addition, gochujang supplement significantly reduced adipocyte size; hepatic triglyceride and total cholesterol levels; the occurrence of fatty liver deposits and steatosis by inhibiting lipogenesis through downregulation of fatty acid synthase, acetly-CoA carboxylase, and glucose-6-phosphate-dehydrogenase. These effects were greater in the gochujang-supplemented groups than the Tabasco hot sauce-supplemented group. The gochujang prepared by nutritious giant embryo rice koji and soybean koji was most effective in terms of antiobesity effects, compared with the other tested gochujangs. In gochujangs, the antiobesity effects are mediated by high levels of secondary metabolites such as isoflavone, soyasaponin, capsaicin, and lysophosphatidylcholine. The current results indicated that the gochujang products have the potential to reduce fat accumulation and obesity.
引用
收藏
页码:233 / 243
页数:11
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