Stimuli-responsive cyclodextrin-based supramolecular assemblies as drug carriers

被引:53
作者
Yuan, Ying [1 ]
Nie, Tianqi [2 ]
Fang, Yifen [3 ]
You, Xinru [4 ]
Huang, Hai [5 ]
Wu, Jun [1 ]
机构
[1] Sun Yat Sen Univ, Sch Biomed Engn, Shenzhen 518107, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Hematol, Shenzhen 518107, Peoples R China
[3] Guangzhou Univ Chinese Med, Clin Sch Med 2, Guangzhou 511436, Peoples R China
[4] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Pediat, Shenzhen 518107, Peoples R China
[5] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Urol, Guangzhou 510120, Peoples R China
基金
中国国家自然科学基金;
关键词
BETA-CYCLODEXTRIN; CONTROLLED-RELEASE; MOLECULAR RECOGNITION; POLYMERIC MATERIALS; DELIVERY SYSTEM; CANCER; LIGHT; NANOPARTICLES; MICELLES; HYDROGEL;
D O I
10.1039/d1tb02683f
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Cyclodextrins (CDs) are widely employed in biomedical applications because of their unique structures. Various biomedical applications can be achieved in a spatiotemporally controlled manner by integrating the host-guest chemistry of CDs with stimuli-responsive functions. In this review, we summarize the recent advances in stimuli-responsive supramolecular assemblies based on the host-guest chemistry of CDs. The stimuli considered in this review include endogenous (pH, redox, and enzymes) and exogenous stimuli (light, temperature, and magnetic field). We mainly discuss the mechanisms of the stimuli-responsive ability and present typical designs of the corresponding supramolecular assemblies for drug delivery and other potential biomedical applications. The limitations and perspectives of CD-based stimuli-responsive supramolecular assemblies are discussed to further promote the translation of laboratory products into clinical applications.
引用
收藏
页码:2077 / 2096
页数:20
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