A young girl with severe polyarteritis nodosa successfully treated with tocilizumab: a case report

被引：5

作者：

Boistault, Margaux ^{[1
]}

Corbeto, Mireia Lopez ^{[2
]}

Quartier, Pierre ^{[1
,3
]}

Arcobe, Laura Berbel ^{[4
]}

Durall, Ariadna Carsi ^{[5
]}

Aeschlimann, Florence A. ^{[1
]}

机构：

[1] Necker Univ Hosp, Assitance Publ Hopitaux Paris, Enfants Malad, Dept Pediat Immunol Hematol & Rheumatol, 149 Rue Sevres, F-75015 Paris, France

[2] Vall dHebron Hosp Campus, Pediat Rheumatol Unit, Barcelona, Spain

[3] Univ Paris, Imagine Inst, Paris, France

[4] Mutua Terrassa Univ Hosp, Rheumatol Dept, Barcelona, Spain

[5] Vall dHebron Hosp Campus, Pediat Hospitalisat Unit, Barcelona, Spain

来源：

PEDIATRIC RHEUMATOLOGY | 2021年 / 19卷 / 01期

关键词：

Polyarteritis nodosa; Child; Tocilizumab; INTERLEUKIN-6; PATIENT;

D O I：

10.1186/s12969-021-00654-7

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background Childhood Polyarteritis nodosa (PAN) is a systemic vasculitis with necrotizing inflammation of medium- and small-sized arteries. Disease evolution may be severe and refractory to standard treatment including prednisone, azathioprine and cyclophosphamide. Case presentation We present the case of a young girl with severe PAN resulting in progressive ischemia and necrosis of fingers and toes. Biological work-up revealed increased acute phase reactants and interleukin-6 levels. She was only partially controlled despite high-dose corticosteroids and cyclophosphamide infusions, and eventually achieved rapid improvement and sustained remission on tocilizumab. Further, we review the current evidence of the interleukin-6-inhibitor tocilizumab for the treatment of PAN. Conclusion Tocilizumab may be an efficient therapeutic option in a subset of treatment-refractory children with PAN.

引用

页数：6

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