QUINPIROLE-INDUCED SENSITIZATION TO NOISY/SPARSE PERIODIC INPUT: TEMPORAL SYNCHRONIZATION AS A COMPONENT OF OBSESSIVE-COMPULSIVE DISORDER

被引：32

作者：

Gu, B. M. ^{[1
]}

Cheng, R. K. ^{[1
]}

Yin, B. ^{[1
]}

Meck, W. H. ^{[1
]}

机构：

[1] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA

来源：

NEUROSCIENCE | 2011年 / 179卷

关键词：

duration discrimination; cyclic behavior; interval timing; rhythm production; timing and time perception; CLOCK-SPEED; INTERNAL CLOCK; DORSOMEDIAL STRIATUM; AGONIST QUINPIROLE; NUCLEUS-ACCUMBENS; NEURAL MECHANISMS; CHECKING BEHAVIOR; RECEPTOR-BINDING; TIMING BEHAVIOR; WORKING-MEMORY;

D O I：

10.1016/j.neuroscience.2011.01.048

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Quinpirole-sensitized rats were tested on a discrete-trials 40-s peak-interval procedure using lever pressing as the instrumental response. Although there was no evidence of rhythmical activity in lever pressing, periodic output was observed in a secondary response (food-cup entries) during the inter-trial interval following the delivery of reinforcement on fixed-interval trials, but not during unreinforced probe trials. This repetitive pattern of behavior with a 40-s period points to the primacy of reinforcement as a time marker and an increased tendency to synchronize to noisy and sparse periodic input as a result of reduced inhibitory control in cortico-striatal circuits following chronic quinpirole administration. Parallels between quinpirole-induced rhythmical behavior and the repetitive motor habits frequently observed in obsessive-compulsive disorder are discussed. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：143 / 150

页数：8

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