Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism

被引：46

作者：

Lejeune, Fabrice ^{[1
,2
]}

机构：

[1] Univ Lille, CHU Lille, CNRS,CANTHER, UMR9020,INSERM,U1277,Canc Heterogene Plast & Resi, F-59000 Lille, France

[2] Inst Pasteur, Unite Tumorigenese & Resistance Traitements, F-59000 Lille, France

来源：

BIOMEDICINES | 2022年 / 10卷 / 01期

关键词：

nonsense-mediated mRNA decay; UPF proteins; regulation; gene expression; therapeutic perspectives; EXON JUNCTION COMPLEX; MAMMALIAN-CELLS; UPF1; SURVEILLANCE; TRANSLATION; MUTATIONS; PROTEIN; PHOSPHORYLATION; IDENTIFICATION; SPECIFICITY;

D O I：

10.3390/biomedicines10010141

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes. This implies that NMD must be subject to regulation in order to allow, under certain physiological conditions, the expression of genes that are normally repressed by NMD. Therapeutically, it might be interesting to express certain NMD-repressed genes or to allow the synthesis of functional truncated proteins. Developing such approaches will require a good understanding of NMD regulation. This review describes the different levels of this regulation in human cells.

引用

页数：11

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