Crystal structure and anti-inflammatory activity of (3E,5E)-1-((4-chlorophenyl)sulfonyl)-3-(pyridin-4-ylmethylene)-5-(2-(trifluoromethyl)benzylidene)piperidin-4-one, C25H18ClF3N2O3S

被引：4
作者：
Zhou, Yan-Qiu [1 ]
Hou, Gui-Ge [2 ]
Meng, Qing-Guo [3 ]
Hou, Yun [1 ]
机构：
[1] Binzhou Med Univ, Sch Basic Med Sci, Yantai 264003, Peoples R China
[2] Binzhou Med Univ, State Adm Tradit Chinese Med China, Sch Pharm, Key Lab Prescript Effect & Clin Evaluat, Yantai 264003, Peoples R China
[3] Yantai Univ, Minist Educ, Collaborat Innovat Ctr Adv Drug Del Ery Syst & Bi, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China
来源：
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES | 2020年 / 235卷 / 02期
关键词：
NF-KAPPA-B; AGENTS; 3,5-BIS(ARYLIDENE)-4-PIPERIDONES; DERIVATIVES;
D O I：
10.1515/ncrs-2019-0716
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
C25H18ClF3N2O3S, monoclinic, P2(1)/n (no. 14), a = 9.9087(5) angstrom, b = 21.7843(10) angstrom, c= 10.2512(6) angstrom, beta= 94.749(5)degrees, V = 2205.2(2) angstrom(3), Z = 4, R-gt(F)= 0.0448, wR(ref)(F-2)= 0.1028, T = 100 K.
引用
收藏
页码：411 / 413
页数：3
相关论文
共 17 条
  • [1] NF-κB and STAT3 - key players in liver inflammation and cancer
    He, Guobin
    Karin, Michael
    [J]. CELL RESEARCH, 2011, 21 (01) : 159 - 168
  • [2] Synthesis, structure and luminescence of Co-crystals with hexagonal channels: arranging disposition and π-π interactions
    Hou, Gui-Ge
    Zhao, Hui-Juan
    Sun, Ju-Feng
    Lin, Dong
    Dai, Xian-Ping
    Han, Jing-Tian
    Zhao, Hui
    [J]. CRYSTENGCOMM, 2013, 15 (03): : 577 - 585
  • [3] Synthesis, crystal structures and anti-inflammatory activity of four 3,5-bis(arylidene)-N-benzenesulfonyl-4-piperidone derivatives
    Li, Ning
    Bai, Xianyong
    Zhang, Lianshuang
    Hou, Yun
    [J]. ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2018, 74 : 1171 - +
  • [4] N-phenylsulfony1-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-κB inhibitors in hepatic carcinoma cell lines
    Li, Ning
    Xin, Wen-Yu
    Yao, Bin-Rong
    Cong, Wei
    Wang, Chun-Hua
    Hou, Gui-Ge
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 155 : 531 - 544
  • [5] Novel dissymmetric 3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo
    Li, Ning
    Xin, Wen-Yu
    Yao, Bin-Rong
    Wang, Chun-Hua
    Cong, Wei
    Zhao, Feng
    Li, Hong-Juan
    Hou, Yun
    Meng, Qing-Guo
    Hou, Gui-Ge
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 147 : 21 - 33
  • [6] Crystal structure of (3E,5E)-3,5-bis(4-cyanobenzylidene)-1-((4-fluorophenyl)sulfonyl)piperidin-4-one, C27H18FN3O3S
    Li, Xiao-Yan
    Meng, Qing-Guo
    Hou, Gui-Ge
    [J]. ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2019, 234 (04): : 771 - 773
  • [7] Crystal structure of 4-((E)-((E)-5-(2-fluorobenzylidene)-1-((4-fluorophenyl) sulfonyl)-4-oxopiperidin-3-ylidene)methyl)benzonitrile, C26H18F2N2O3S
    Liu, Lian-Dong
    Liu, Shu-Lian
    Hou, Gui-Ge
    [J]. ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2018, 233 (06): : 1063 - 1065
  • [8] The Essential Medicinal Chemistry of Curcumin
    Nelson, Kathryn M.
    Dahlin, Jayme L.
    Bisson, Jonathan
    Graham, James
    Pauli, Guido F.
    Walters, Michael A.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (05) : 1620 - 1637
  • [9] Rigaku O., 2017, CrysAlisPRO
  • [10] A short history of SHELX
    Sheldrick, George M.
    [J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 : 112 - 122
12