The dynamics of cholesterol molecules near the surface of protein farnesyltransferase - Computer simulation

被引：1

作者：

Raczynski, Przemyslaw ^{[1
]}

Gburski, Zygmunt ^{[1
]}

机构：

[1] Silesian Univ, Inst Phys, PL-40007 Katowice, Poland

来源：

BIOMOLECULAR ENGINEERING | 2007年 / 24卷 / 05期

关键词：

protein; cholesterol; cholesterol lodgment; molecular dynamics; computer simulation;

D O I：

10.1016/j.bioeng.2007.08.009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have made the molecular dynamics (MD) simulations for the cluster of cholesterols localized near the protein farnesyltransferase (1 FT2) at the physiological temperature T = 309.75 K. We have observed that the cholesterol molecules form a lodgment on the surface of protein. Several physical characteristics of the deposited cholesterol cluster have been calculated among those: the mean square displacement, diffusion coefficient, linear and angular velocity autocorrelation function and their Fourier transforms. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：568 / 571

页数：4

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