Tissue engineering of the cornea

被引:91
作者
Nishida, K [1 ]
机构
[1] Osaka Univ, Sch Med, Dept Ophthalmol, Suita, Osaka 5650081, Japan
关键词
corneal epithelium; cultivated cell; stem cell; temperature-responsive culture surface; tissue engineering; transplantation;
D O I
10.1097/00003226-200310001-00005
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Tissue engineering of the cornea represents a paradigm shift in medical treatment to overcome the present disadvantages of corneal transplantation, primarily immune rejection and the shortage of donor corneas. Transplantation of cultivated corneal epithelial cells expanded ex vivo from corneal epithelial stem cells has been developed and has already entered the clinical realm. However, there remain many hurdles to be overcome. The author and colleagues are developing a method to transplant cultivated cell sheets that uses a temperature-responsive culture dish. This article reviews the present situation regarding tissue-engineered corneal epithelium and introduces the results of this program of research.
引用
收藏
页码:S28 / S34
页数:7
相关论文
共 15 条
  • [1] EXISTENCE OF SLOW-CYCLING LIMBAL EPITHELIAL BASAL CELLS THAT CAN BE PREFERENTIALLY STIMULATED TO PROLIFERATE - IMPLICATIONS ON EPITHELIAL STEM-CELLS
    COTSARELIS, G
    CHENG, SZ
    DONG, G
    SUN, TT
    LAVKER, RM
    [J]. CELL, 1989, 57 (02) : 201 - 209
  • [2] KENYON KR, 1989, OPHTHALMOLOGY, V96, P709
  • [3] Kenyon KR, 1989, OPHTHALMOLOGY, V96, P722
  • [4] Cultivated corneal epithelial stem cell transplantation in ocular surface disorders
    Koizumi, N
    Inatomi, T
    Suzuki, T
    Sotozono, C
    Kinoshita, S
    [J]. OPHTHALMOLOGY, 2001, 108 (09) : 1569 - 1574
  • [5] NISHIDA K, 2003, IN PRESS TRANSPLANTA
  • [6] Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium
    Pellegrini, G
    Traverso, CE
    Franzi, AT
    Zingirian, M
    Cancedda, R
    DeLuca, M
    [J]. LANCET, 1997, 349 (9057) : 990 - 993
  • [7] Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency
    Rama, P
    Bonini, S
    Lambiase, A
    Golisano, O
    Paterna, P
    De Luca, M
    Pellegrini, G
    [J]. TRANSPLANTATION, 2001, 72 (09) : 1478 - 1485
  • [8] SERIAL CULTIVATION OF STRAINS OF HUMAN EPIDERMAL KERATINOCYTES - FORMATION OF KERATINIZING COLONIES FROM SINGLE CELLS
    RHEINWALD, JG
    GREEN, H
    [J]. CELL, 1975, 6 (03) : 331 - 344
  • [9] DIFFERENTIATION-RELATED EXPRESSION OF A MAJOR 64K CORNEAL KERATIN INVIVO AND IN CULTURE SUGGESTS LIMBAL LOCATION OF CORNEAL EPITHELIAL STEM-CELLS
    SCHERMER, A
    GALVIN, S
    SUN, TT
    [J]. JOURNAL OF CELL BIOLOGY, 1986, 103 (01) : 49 - 62
  • [10] Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease
    Schwab, IR
    Reyes, M
    Isseroff, RR
    [J]. CORNEA, 2000, 19 (04) : 421 - 426