IgE regulation and roles in asthma pathogenesis

被引:146
作者
Oettgen, HC [1 ]
Geha, RS [1 ]
机构
[1] Harvard Univ, Childrens Hosp, Sch Med, Div Immunol, Boston, MA 02115 USA
关键词
IgE; asthma; allergy; IL-4; receptor; IL-13; CD40; ligand;
D O I
10.1067/mai.2001.113759
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Asthma and the predisposition to produce IgE are inherited as linked traits in families. In patients IgE levels correlate with asthma severity and bronchial hyperresponsiveness. The concept that IgE plays a critical role in asthma pathogenesis has driven the development of IgE blockers, which are currently being introduced into clinical use. This review focuses on the mechanisms whereby IgE participates both in immediate hypersensitivity responses in the airways and in the induction of chronic allergic bronchial inflammation. The molecular genetic events that give rise to IgE production by B cells and the cellular and cytokine factors that support IgE production in the bronchial mucosal microenvironment are discussed. It is clear that much remains to be learned regarding the roles of IgE in asthma and the genetic and environmental influences that lead to its production. Over the next few years, the emerging experience with anti-IgE in patients mill provide a more complete understanding of the mechanisms whereby IgE contributes to disease, as well as the therapeutic potential of its inhibition.
引用
收藏
页码:429 / 440
页数:12
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