Melohenryines A and B, two new indole alkaloids from Melodinus henryi

被引:9
作者
Guo, Ling-Li [1 ]
Yuan, Yu-Xi [2 ]
He, Hong-Ping [2 ]
Li, Shun-Lin [1 ]
Zhang, Yu [1 ]
Hao, Xiao-Jiang [1 ]
机构
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
[2] Yunnan Univ TCM, Kunming 650500, Yunnan, Peoples R China
基金
中国国家自然科学基金;
关键词
Monoterpenoid indole alkaloids; Melohenryines A and B; Melodinus henryi; BISINDOLE ALKALOIDS; TENUICAUDATUS; HEMSLEYANUS;
D O I
10.1016/j.phytol.2017.07.001
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Two new monoterpenoid indole alkaloids, melohenryines A and B (1 and 2), along with six known indole alkaloids, were isolated from the twigs and leaves of Melodinus henryi. Structures of the new alkaloids were established by extensive spectroscopic techniques including NMR spectroscopy and mass spectrometry. Melohenryine A (1) represents the first example of monoterpenoid indole alkaloids characterized an ester carbonyl group at C-19 position. All of the new compounds were evaluated for in vitro cytotoxicity against several human cancer cell lines.
引用
收藏
页码:179 / 182
页数:4
相关论文
共 17 条
[1]   C-13 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY OF NATURALLY OCCURRING SUBSTANCES .34. MONOMERIC QUINOLINIC MELODINUS ALKALOIDS [J].
DAUDON, M ;
MEHRI, MH ;
PLAT, MM ;
HAGAMAN, EW ;
SCHELL, FM ;
WENKERT, E .
JOURNAL OF ORGANIC CHEMISTRY, 1975, 40 (19) :2838-2839
[2]  
Dewick P.M., 2009, ALKALOIDS MED NATURA, P369
[3]   Cytotoxic Indole Alkaloids from Melodinus tenuicaudatus [J].
Feng, Tao ;
Li, Yan ;
Wang, Yuan-Yuan ;
Cai, Xiang-Hai ;
Liu, Ya-Ping ;
Luo, Xiao-Dong .
JOURNAL OF NATURAL PRODUCTS, 2010, 73 (06) :1075-1079
[4]   Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis [J].
Fu, Yan-hui ;
Li, Shun-lin ;
Li, Shi-fei ;
He, Hong-ping ;
Di, Ying-tong ;
Zhang, Yu ;
Hao, Xiao-jiang .
FITOTERAPIA, 2014, 98 :45-52
[5]   Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia [J].
Fu, Yan-hui ;
Di, Ying-tong ;
He, Hong-ping ;
Li, Shun-lin ;
Zhang, Yu ;
Hao, Xiao-jiang .
JOURNAL OF NATURAL PRODUCTS, 2014, 77 (01) :57-62
[6]   Indole alkaloids from Ervatamia chinensis [J].
Guo, Ling-Li ;
He, Hong-Ping ;
Di, Ying-Tong ;
Li, Shi-Fei ;
Cheng, Yuan-Yuan ;
Yang, Wei ;
Li, Yan ;
Yu, Jian-Ping ;
Zhang, Yu ;
Hao, Xiao-Jiang .
PHYTOCHEMISTRY, 2012, 74 :140-145
[7]   ALKALOIDS FROM MELODINUS-HEMSLEYANUS [J].
GUO, LW ;
ZHOU, YL .
PHYTOCHEMISTRY, 1993, 34 (02) :563-566
[8]  
HE X, 1992, ACTA CHIM SINICA, V50, P96
[9]  
Li P.-T., 1995, FLORA CHINA, V16, P147
[10]   Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi [J].
Liu, Ya-Ping ;
Yue, Grace Gar-Lee ;
Lee, Julia Kin-Ming ;
Feng, Tao ;
Zhao, Yun-Li ;
Li, Yan ;
Lau, Clara Bik-San ;
Luo, Xiao-Dong .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (20) :4895-4898