An Evaluation of Family-Based Treatment for OCD in Japan: A Pilot Randomized Controlled Trial

被引：10

作者：

Kobayashi, Yuki ^{[1
,2
]}

Kanie, Ayako ^{[1
]}

Nakagawa, Atsuo ^{[2
,3
]}

Takebayashi, Yoshitake ^{[1
,4
]}

Shinmei, Issei ^{[5
,6
]}

Nakayama, Noriko ^{[1
]}

Yamaguchi, Keiko ^{[1
]}

Nakayama, Chiaki ^{[1
]}

Hirabayashi, Naotsugu ^{[1
,7
]}

Mimura, Masaru ^{[2
]}

Horikoshi, Masaru ^{[1
]}

机构：

[1] Natl Ctr Neurol & Psychiat, Natl Ctr Cognit Behav Therapy & Res, Tokyo, Japan

[2] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan

[3] Keio Univ Hosp, Clin & Translat Res Ctr, Tokyo, Japan

[4] Fukushima Med Univ, Sch Med, Dept Hlth Risk Commun, Fukushima, Japan

[5] TCBT Counseling Off, Tokyo, Japan

[6] Natl Ctr Neurol & Psychiat, Dept Neurol, Tokyo, Japan

[7] Natl Ctr Neurol & Psychiat, Natl Ctr Hosp, Tokyo, Japan

来源：

FRONTIERS IN PSYCHIATRY | 2020年 / 10卷

关键词：

obsessive-compulsive disorder; family-based treatment; exposure response prevention; pilot randomized controlled trial; treatment; OBSESSIVE-COMPULSIVE DISORDER; QUALITY-OF-LIFE; ACCOMMODATION SCALE; PSYCHOMETRIC PROPERTIES; RESPONSE PREVENTION; VERSION; INVOLVEMENT; CHILDREN; INTERVENTION; METAANALYSIS;

D O I：

10.3389/fpsyt.2019.00932

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Although family involvement in the treatment of obsessive-compulsive disorder (OCD) produces a reduction in OCD symptoms and has significant effects on global functioning, few studies have focused on family intervention as part of OCD treatment in Japan. This study aims to examine the feasibility and efficacy of the family-based exposure and response prevention (FERP) program for adult patients with OCD and their family members. Design: Randomized controlled pilot study. Methods: A total of 18 outpatients aged 18-65 years with a primary diagnosis of OCD and one family member of each patient were randomized to an intervention group or a control group (1:1). The intervention group received the FERP program, which consisted of 16 weekly face-to-face cognitive behavioral therapy (CBT) sessions, including eight joint sessions with family members, in addition to treatment-as-usual (TAU). The control group received TAU alone. The primary outcome was the alleviation of OCD symptoms, as measured by changes in the total Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score from baseline to posttreatment. Analyses were provided on an intention-to-treat basis, and linear mixed models were used to test for significant group differences. Results: After 16 weeks, patients allocated to the FERP program showed improvement in OCD symptom severity, as measured by the total change score of the Y-BOCS (Hedges' g = -1.58), as compared to the control group. Two patients (22.2%) in the FERP group reached remission, and five patients (55.6%) in the FERP group achieved treatment response. Clinical global improvement measured by the FAS-SR scores, K6 scores, and CGI-S scores was also observed (Hedges' g = -1.35, -1.25, and -1.26, respectively) in the FERP group as compared to the control group. The dropout rate from the study was low (n = 2, 11.8%), and no adverse events were reported in the FERP group. Conclusion: Our results suggest that FERP may be an effective program for reducing patients' OCD symptoms.

引用

页数：10

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