Dynamic Peptides as Biomimetic Carbohydrate Receptors

被引：73
|
作者：
Rauschenberg, Melanie [1 ]
Bomke, Susanne [2 ]
Karst, Uwe [2 ]
Ravoo, Bart Jan [1 ]
机构：
[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany
[2] Univ Munster, Inst Anorgan & Analyt Chem, D-48149 Munster, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 40期
关键词：
carbohydrates; dynamic combinatorial chemistry; molecular recognition; peptides; COMBINATORIAL LIBRARIES; SYNTHETIC LECTIN; NONCOVALENT INTERACTIONS; RECOGNITION; IDENTIFICATION; AMPLIFICATION; GENERATION; DISULFIDE; EXCHANGE; WATER;
D O I：
10.1002/anie.201002847
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Finding the needle in the haystack:A dynamic combinatorial library(DCL)of peptides was created using the disulfide-exchange reaction of cysteines. Three cyclic peptides were found to be selective receptors for carbohydrates in water. One ofthese, HisHis, formed preferentially in a DCL in the presence of the neurotrans- mitter NANA. © 2010 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim.
引用
收藏
页码：7340 / 7345
页数：6
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