The Role of Gut Microbiota in Aging and Aging Related Neurodegenerative Disorders: Insights from Drosophila Model

被引：14
作者：
Kong, Yan [1 ]
Wang, Liyuan [1 ]
Jiang, Baichun [2 ]
机构：
[1] Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Peoples R China
[2] Shandong Univ, Sch Basic Med Sci, Dept Mol Med & Genet, Key Lab Expt Teratol,Minist Educ, Jinan 250012, Peoples R China
来源：
LIFE-BASEL | 2021年 / 11卷 / 08期
基金：
中国国家自然科学基金;
关键词：
aging; neurodegeneration; Drosophila; microbiota; Alzheimer's disease; Parkinson's disease; LIFE-SPAN; ALZHEIMERS; DISEASE; MELANOGASTER; HOMEOSTASIS; EXPRESSION; MICROGLIA; HEALTHY; STRAIN; GROWTH;
D O I：
10.3390/life11080855
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Aging is characterized by a time dependent impairment of physiological function and increased susceptibility to death. It is the major risk factor for neurodegeneration. Neurodegenerative disorders including Alzheimer's disease (AD) and Parkinson's disease (PD) are the main causes of dementia in the old population. Gut microbiota is a community of microorganisms colonized in the gastrointestinal (GI) tract. The alteration of gut microbiota has been proved to be associated with aging and aging related neurodegeneration. Drosophila is a powerful tool to study microbiota-mediated physiological and pathological functions. Here, we summarize the recent advances using Drosophila as model organisms to clarify the molecular mechanisms and develop a therapeutic method targeting microbiota in aging and aging-related neurodegenerative disorders.
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页数：12
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