Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

被引：41

作者：

Oliviero, Giorgia ^{[1
]}

Amato, Jussara ^{[1
]}

Borbone, Nicola ^{[1
]}

D'Errico, Stefano ^{[1
]}

Galeone, Aldo ^{[1
]}

Mayol, Luciano ^{[1
]}

Haider, Shozeb ^{[2
]}

Olubiyi, Olujide ^{[2
]}

Hoorelbeke, Bart ^{[3
]}

Balzarini, Jan ^{[3
]}

Piccialli, Gennaro ^{[1
]}

机构：

[1] Univ Naples Federico 2, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ London, Sch Pharm, CRUK Biomol Struct Grp, London WC1N 1AX, England

[3] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 47期

关键词：

GUANOSINE-QUARTET STRUCTURE; MEDIATED CELL-FUSION; ANTI-HIV-1; ACTIVITY; IN-VITRO; OLIGODEOXYRIBONUCLEOTIDES; ENVELOPE; HEXADEOXYRIBONUCLEOTIDES; 5-END-MODIFICATIONS; 5'-END-MODIFICATION; INTEGRASE;

D O I：

10.1039/c0cc02866e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The biophysical and biological properties of unprecedented anti-HIV aptamers are presented. The most active aptamer (1L) shows a significant affinity to the HIV protein gp120.

引用

页码：8971 / 8973

页数：3

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