Role of Cyclic Nucleotides in the Effect of Hydrogen Sulfide on Contractions of Rat Jejunum

被引：5

作者：

Gabitova, D. M. ^{[1
,2
]}

Shaidullov, I. F. ^{[1
,2
]}

Sabirullina, G. I. ^{[1
]}

Shafigullin, M. U. ^{[1
]}

Sitdikov, F. G. ^{[2
]}

Sitdikova, G. F. ^{[1
]}

机构：

[1] Kazan Volga Reg Fed Univ, Dept Human & Anim Physiol, Kazan, Republic Of Tat, Russia

[2] Kazan Volga Reg Fed Univ, Dept Human Hlth Protect, Kazan, Republic Of Tat, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 163卷 / 01期

关键词：

hydrogen sulfide; jejunum; carbachol-induced contractions; cAMP; cGMP; PITUITARY-TUMOR CELLS; H2S; CHANNELS; CALCIUM; MUSCLE;

D O I：

10.1007/s10517-017-3726-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the role of cyclic nucleotides in the influence of hydrogen sulfide (H2S) donor, sodium hydrosulfide (NaHS, 200 mu M), on motor activity of rat jejunum. NaHS reduced spontaneous and carbachol-induced contractions of rat jejunum segment, which suggests that H2S can act through mechanisms involving muscarinic receptor activation. Against the background of a membrane-penetrating non-hydrolyzable cAMP analogue or under conditions of adenylate cyclase blockade, the inhibitory effect of NaHS on the carbachol-induced contractions was maintained. Against the background of elevated cGMP concentration or guanylate cyclase inhibition, the reduction of carbachol-induced contractions upon exposure to NaHS was less pronounced than in control. It was hypothesized that H2S induces relaxation of carbachol-induced jejunum contractions, affecting protein kinase G targets or activating cGMP synthesis.

引用

页码：14 / 17

页数：4

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