Novel degraded polycyclic polyprenylated acylphloroglucinol and new polyprenylated benzophenone from Hypericum sampsonii

被引：9

作者：

Zhang, Jun-Sheng ^{[1
]}

Huang, Jia-Luo ^{[1
]}

Zou, Yi-Hong ^{[1
]}

Liu, Xin ^{[1
]}

Ahmed, Abrar ^{[1
]}

Tang, Gui-Hua ^{[1
]}

Yin, Sheng ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2017年 / 21卷

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

Hypericum sampsonii; Degraded polycyclic polyprenylated; acylphloroglucinol; Polyprenylated benzophenone; NO inhibitory activity; BENZOYLPHLOROGLUCINOL DERIVATIVES; XANTHONES; INHIBITORS;

D O I：

10.1016/j.phytol.2017.06.023

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Norhypersampsone A (1), a novel degraded polycyclic polyprenylated acylphloroglucinol (PPAP) derivative, 3-(2-hydroxy-7-methyl-3-methyleneoct-6-enyl)-5-isoprenyl-2,4,6-trihydroxybenzophenone (2), a new poly-prenylated benzophenone derivative, and nine known compounds (3-11) were isolated from Hypericum sampsonii. Their structures were elucidated by comprehensive spectroscopic techniques. Compound 1 represents a novel cyclohexenone monocyclic-PPAP formed by losing the fragment of C-2-C-4 and the side chains at C-3 and C-5 in the phloroglucinol ring. The results of the inhibitory effects of compounds 1-11 on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages showed that compounds 1, 6-8, and 10 exhibited weak activities with IC50 values in the range of 20.3-37.1 mu M.

引用

页码：190 / 193

页数：4

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