Receptor activity modifying proteins

被引：157
作者：
Sexton, PM [1 ]
Albiston, A
Morfis, M
Tilakaratne, N
机构：
[1] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Melbourne, Vic 3010, Australia
[2] Univ Melbourne, Dept Pharmacol, Mol Pharmacol Lab, Melbourne, Vic 3010, Australia
来源：
CELLULAR SIGNALLING | 2001年 / 13卷 / 02期
基金：
英国医学研究理事会;
关键词：
receptor activity modifying protein; G protein-coupled receptor; calcitonin receptor-like receptor; calcitonin receptor; calcitonin; amylin; calcitonin gene-related peptide; adrenomedullin;
D O I：
10.1016/S0898-6568(00)00143-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Our understandings of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples are those involving receptor activity modifying proteins (RAMPs). RAMP association with the calcitonin (CT) receptor-like receptor (CRLR) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes. a similar function has been ascribed to RAMP interaction with the CT receptor (CTR) gene product. This review examines our current slate of knowledge of the mechanisms underlying RAMP function. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：73 / 83
页数：11
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