Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

被引：432

作者：

Bosurgi, Lidia ^{[1
]}

Cao, Y. Grace ^{[1
]}

Cabeza-Cabrerizo, Mar ^{[1
]}

Tucci, Andrea ^{[1
]}

Hughes, Lindsey D. ^{[1
]}

Kong, Yong ^{[2
]}

Weinstein, Jason S. ^{[1
]}

Licona-Limon, Paula ^{[1
,10
]}

Schmid, Edward T. ^{[1
]}

Pelorosso, Facundo ^{[3
]}

Gagliani, Nicola ^{[4
,5
]}

Craft, Joseph E. ^{[1
,6
]}

Flavell, Richard A. ^{[1
,7
]}

Ghosh, Sourav ^{[8
,9
]}

Rothlin, Carla V. ^{[1
,9
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, 333 Cedar St, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, WM Keck Fdn Biotechnol Resource Lab, Dept Mol Biophys & Biochem, 333 Cedar St, New Haven, CT 06520 USA

[3] Univ Buenos Aires, Fac Med, Inst Farmacol, Buenos Aires, DF, Argentina

[4] Univ Med Ctr Hamburg Eppendorf, Dept Med 1, D-20246 Hamburg, Germany

[5] Univ Med Ctr Hamburg Eppendorf, Dept Gen Visceral & Thorac Surg, D-20246 Hamburg, Germany

[6] Yale Univ, Sch Med, Dept Internal Med Rheumatol, 333 Cedar St, New Haven, CT 06520 USA

[7] Yale Univ, Sch Med, Howard Hughes Med Inst, 333 Cedar St, New Haven, CT 06520 USA

[8] Yale Univ, Sch Med, Dept Neurol, 333 Cedar St, New Haven, CT 06520 USA

[9] Yale Univ, Sch Med, Dept Pharmacol, 333 Cedar St, New Haven, CT 06520 USA

[10] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biol Celular & Desarrollo, Mexico City 04510, DF, Mexico

来源：

SCIENCE | 2017年 / 356卷 / 6342期

关键词：

RECEPTOR; EXPRESSION; POLARIZATION; RECOGNITION; ACTIVATION;

D O I：

10.1126/science.aai8132

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tissue repair is a subset of a broad repertoire of interleukin-4 (IL-4)-and IL-13-dependent host responses during helminth infection. Here we show that IL-4 or IL-13 alone was not sufficient, but IL-4 or IL-13 together with apoptotic cells induced the tissue repair program in macrophages. Genetic ablation of sensors of apoptotic cells impaired the proliferation of tissue-resident macrophages and the induction of anti-inflammatory and tissue repair genes in the lungs after helminth infection or in the gut after induction of colitis. By contrast, the recognition of apoptotic cells was dispensable for cytokine-dependent induction of pattern recognition receptor, cell adhesion, or chemotaxis genes in macrophages. Detection of apoptotic cells can therefore spatially compartmentalize or prevent premature or ectopic activity of pleiotropic, soluble cytokines such as IL-4 or IL-13.

引用

页码：1072 / +

页数：5

共 22 条

[1] Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer [J].