Glucocorticoid Regulation of Clock Gene Expression in the Mammalian Limbic Forebrain

Glucocorticoids regulate a wide variety of functions, including synaptic plasticity, hypothalamic-pituitary-adrenal axis activation, conditional fear learning, metabolism, and sensitization to drugs of abuse. The diurnal secretion of glucocorticoids, driven by the mammalian master clock located in the suprachiasmatic nucleus of the hypothalamus, has been shown to induce and entrain clock gene expression in peripheral tissues. However, little attention has been given to the form and function of centrally located subordinate oscillators, and the synchronizing factors that influence them. Here we review findings that implicate glucocorticoids in the circadian regulation of clock genes in select oscillators in the limbic forebrain and propose mechanisms whereby glucocorticoids can feed back on rhythms downstream from the master clock and possibly alter the functional output of these nuclei.