α-melanocyte stimulating hormone modulates the central acyl ghrelin-induced stimulation of feeding, gastrointestinal motility, and colonic secretion

被引：11
|
作者：
Huang, Hsien-Hao [1 ,2 ]
Chen, Liang-Yu [3 ,4 ]
Doong, Ming-Luen [5 ]
Chang, Shi-Chuan [6 ,7 ]
Chen, Chih-Yen [8 ,9 ,10 ]
机构：
[1] Natl Yang Ming Univ Med, Inst Clin Med, Taipei, Taiwan
[2] Taipei Vet Gen Hosp, Dept Emergency Med, Taipei, Taiwan
[3] Natl Yang Ming Univ, Aging & Hlth Res Ctr, Taipei, Taiwan
[4] Taipei Vet Gen Hosp, Ctr Geriatr & Gerontol, Taipei, Taiwan
[5] Natl Yang Ming Univ, Sch Med, Inst Physiol, Taipei, Taiwan
[6] Natl Yang Ming Univ, Sch Med, Inst Emergency & Crit Med, Taipei, Taiwan
[7] Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan
[8] Taipei Vet Gen Hosp, Div Gastroenterol & Hepatol, Dept Med, Taipei, Taiwan
[9] Natl Yang Ming Univ, Sch Med, Fac Med, Taipei, Taiwan
[10] Taiwan Assoc Study Small Intestinal Dis, Guishan, Taiwan
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2017年 / 11卷
关键词：
acyl ghrelin; colon transit time; fecal pellet output; food intake; gastric emptying; intracerebroventricular; small intestinal transit; alpha-melanocyte stimulating hormone; AGOUTI-RELATED PROTEIN; CONSCIOUS FED RATS; CENTRAL MELANOCORTIN RECEPTORS; NEUROPEPTIDE-Y; FOOD-INTAKE; PEPTIDE-YY; IN-VIVO; INTESTINAL TRANSIT; ARCUATE NUCLEUS; PERIPHERAL GHRELIN;
D O I：
10.2147/DDDT.S143749
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Background: Acyl ghrelin-induced intake depends on hypothalamic neuropeptide Y and agouti-related protein (AgRP) neurotransmitters. Intracerebroventricular (ICV) injection of AgRP increases feeding through competitive antagonism at melanocortin receptors. ICV administration of alpha-melanocyte stimulating hormone (alpha-MSH), a natural antagonist of AgRP, may modulate the acyl ghrelin-induced orexigenic effect. Objective: This study aimed to investigate the modulating effect of alpha-MSH on the central acyl ghrelin-induced food intake, gastrointestinal motility, and colonic secretion in rats. Methods and procedures: We examined the effects of alpha-MSH and acyl ghrelin on food intake, gastric emptying, small intestinal transit, colonic motility, and secretion in conscious rats with a chronic implant of ICV catheters. Results: ICV injection of O-n-octanoylated ghrelin (0.1 nmol/rat) significantly increased the cumulative food intake up to 8 h (P<0.01), enhanced non-nutrient semi-liquid gastric emptying (P<0.001), increased the geometric center and running percentage of small intestinal transit (P<0.001), accelerated colonic transit time (P<0.05), and increased fecal pellet output (P<0.01) and total fecal weight (P<0.01). Pretreatment with ICV injection of alpha-MSH (1.0 and 2.0 nmol/rat) attenuated the acyl ghrelin-induced hyperphagic effect, fecal pellet output, and total fecal weight, while higher dose of alpha-MSH (2.0 nmol/rat) attenuated the increase in the geometric center of small intestinal transit (P<0.01). However, neither dose of alpha-MSH altered acyl ghrelin-stimulated gastroprokinetic effect, increase in the running percentage of small intestinal transit, nor accelerated colonic transit time. Conclusion: alpha-MSH is involved in central acyl ghrelin-elicited feeding, small intestinal transit, fecal pellet output, and fecal weight. alpha-MSH does not affect central acyl ghrelin-induced acceleration of gastric emptying and colonic transit time in rats.
引用
收藏
页码：2377 / 2386
页数：10
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