Breast cancer risk reduction - is it feasible to initiate a randomised controlled trial of a lifestyle intervention programme (ActWell) within a national breast screening programme?

被引:27
作者
Anderson, Annie S. [1 ]
Macleod, Maureen [1 ]
Mutrie, Nanette [2 ]
Sugden, Jacqueline [1 ]
Dobson, Hilary [3 ]
Treweek, Shaun [4 ]
O'Carroll, Ronan E. [5 ]
Thompson, Alistair [6 ]
Kirk, Alison [7 ]
Brennan, Graham [8 ]
Wyke, Sally [8 ]
机构
[1] Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Canc Div,Ctr Res Canc Prevent & Screening, Dundee DD1 9SY, Scotland
[2] Univ Edinburgh, Moray House Sch Educ, Phys Act Hlth Res Ctr, Edinburgh EH8 8AQ, Midlothian, Scotland
[3] West Scotland Breast Screening Serv, Glasgow G1 2QT, Lanark, Scotland
[4] Univ Aberdeen, Hlth Serv Res Unit, Aberdeen AB25 2ZD, Scotland
[5] Univ Stirling, Sch Nat Sci, Div Psychol, Stirling FK9 4LA, Scotland
[6] Univ Dundee, Ninewells Hosp & Med Sch, Dundee Canc Ctr, Dept Surg, Dundee DD1 9SY, Scotland
[7] Univ Strathclyde, Sch Psychol Sci & Hlth, Phys Act Hlth Res Grp, Glasgow G1 1QE, Lanark, Scotland
[8] Univ Glasgow, Coll Social Sci, Inst Hlth & Wellbeing, Glasgow G12 8RS, Lanark, Scotland
来源
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY | 2014年 / 11卷
关键词
Breast cancer; Physical activity; Body weight; Alcohol; Sedentary time; ADULT WEIGHT CHANGE; PHYSICAL-ACTIVITY; HEALTH; PREVENTION; BEHAVIOR; IMPACT; DIET;
D O I
10.1186/s12966-014-0156-2
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Breast cancer is the most commonly diagnosed cancer and the second cause of cancer deaths amongst women in the UK. The incidence of the disease is increasing and is highest in women from least deprived areas. It is estimated that around 42% of the disease in post-menopausal women could be prevented by increased physical activity and reductions in alcohol intake and body fatness. Breast cancer control endeavours focus on national screening programmes but these do not include communications or interventions for risk reduction. This study aimed to assess the feasibility of delivery, indicative effects and acceptability of a lifestyle intervention programme initiated within the NHS Scottish Breast Screening Programme (NHSSBSP). Methods: A 1: 1 randomised controlled trial (RCT) of the 3 month ActWell programme (focussing on body weight, physical activity and alcohol) versus usual care conducted in two NHSSBSP sites between June 2013 and January 2014. Feasibility assessments included recruitment, retention, and fidelity to protocol. Indicative outcomes were measured at baseline and 3 month follow-up (body weight, waist circumference, eating and alcohol habits and physical activity). At study end, a questionnaire assessed participant satisfaction and qualitative interviews elicited women's, coaches' and radiographers' experiences. Statistical analysis used Chi squared tests for comparisons in proportions and paired t tests for comparisons of means. Linear regression analyses were performed, adjusted for baseline values, with group allocation as a fixed effect. Results: A pre-set recruitment target of 80 women was achieved within 12 weeks and 65 (81%) participants (29 intervention, 36 control) completed 3 month assessments. Mean age was 58 +/- 5.6 years, mean BMI was 29.2 +/- 7.0 kg/m(2) and many (44%) reported a family history of breast cancer. The primary analysis (baseline body weight adjusted) showed a significant between group difference favouring the intervention group of 2.04 kg (95% CI -3.24 kg to -0.85 kg). Significant, favourable between group differences were also detected for BMI, waist circumference, physical activity and sitting time. Women rated the programme highly and 70% said they would recommend it to others. Conclusions: Recruitment, retention, indicative results and participant acceptability support the development of a definitive RCT to measure long term effects.
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页数:15
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