Extension of the Lifespan of Caenorhabditis elegans by the Use of Electrolyzed Reduced Water

被引：17

作者：

Yan, Hanxu ^{[1
]}

Tian, Huaize ^{[2
]}

Kinjo, Tomoya ^{[1
]}

Hamasaki, Takeki ^{[2
]}

Tomimatsu, Kosuke ^{[1
]}

Nakamichi, Noboru ^{[3
]}

Teruya, Kiichiro ^{[1
,2
]}

Kabayama, Shigeru ^{[3
]}

Shirahata, Sanetaka ^{[1
,2
]}

机构：

[1] Kyushu Univ, Grad Sch Syst Life Sci, Higashi Ku, Fukuoka 8128581, Japan

[2] Kyushu Univ, Fac Agr, Dept Genet Resources Technol, Higashi Ku, Fukuoka 8128581, Japan

[3] Nihon Trim Co Ltd, Kita Ku, Osaka 5310076, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2010年 / 74卷 / 10期

关键词：

electrolyzed reduced water; Caenorhabditis elegans; lifespan; reactive oxygen species; OXIDATIVE STRESS; HYDROGEN; MODEL; DNA; ANTIOXIDANT; INHALATION; PREVENTS; DAMAGE;

D O I：

10.1271/bbb.100250

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electrolyzed reduced water (ERW) has attracted much attention because of its therapeutic effects. In the present study, a new culture medium, which we designated Water medium, was developed to elucidate the effects of ERW on the lifespan of Caenorhabditis elegans. Wild-type C. elegans had a significantly shorter lifespan in Water medium than in conventional S medium. However, worms cultured in ERW-Water medium exhibited a significantly extended lifespan (from 11% to 41%) compared with worms cultured in ultrapure water-Water medium. There was no difference between the lifespans of worms cultured in ERW-S medium and ultrapure water-S medium. Nematodes cultured in ultrapure water-Water medium showed significantly higher levels of reactive oxygen species than those cultured in ultrapure water-S medium. Moreover, ERW-Water medium significantly reduced the ROS accumulation induced in the worms by paraquat, suggesting that ERW-Water medium extends the longevity of nematodes at least partly by scavenging ROS.

引用

页码：2011 / 2015

页数：5

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