Immune responses to endogenous retroelements: taking the bad with the good

被引：180

作者：

Kassiotis, George ^{[1
,2
]}

Stoye, Jonathan P. ^{[2
,3
]}

机构：

[1] Francis Crick Inst, Retroviral Immunol, Mill Hill Lab, London NW7 1AA, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Med, Fac Med, London W2 1PG, England

[3] Francis Crick Inst, Retrovirus Host Interact, Mill Hill Lab, London NW7 1AA, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

AICARDI-GOUTIERES SYNDROME; EXOGENOUS RETROVIRUSES; CELL RESPONSES; RETROTRANSPOSONS; CANCER; GENE; IDENTIFICATION; EVOLUTION; ANTIGEN; EXPRESSION;

D O I：

10.1038/nri.2016.27

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ultimate form of parasitism and evasion of host immunity is for the parasite genome to enter the germ line of the host species. Retroviruses have invaded the host germ line on the grandest scale, and this is evident in the extraordinary abundance of endogenous retroelements in the genome of all vertebrate species that have been studied. Many of these endogenous retroelements have retained viral characteristics; some also the capacity to replicate and, consequently, the potential to trigger host innate and adaptive immune responses. However, although retroelements are mainly recognized for their pathogenic potential, recent evidence suggests that this 'enemy within' may also have beneficial roles in tuning host immune reactivity. In this Review, we discuss how the immune system recognizes and is shaped by endogenous retroelements.

引用

页码：207 / 219

页数：13

共 116 条

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