Daytime Glycemic Variability and Frailty in Older Patients with Diabetes: a Pilot Study Using Continuous Glucose Monitoring

被引：18

作者：

Chung, Seung Min ^{[1
]}

Lee, Yun Hee ^{[2
]}

Kim, Chang Oh ^{[3
]}

Lee, Ji Yeon ^{[3
]}

Jin, Sang-Man ^{[4
]}

Yoo, Seung-Hyun ^{[5
]}

Moon, Jun Sung ^{[1
]}

Kim, Kwang Joon ^{[3
]}

机构：

[1] Yeungnam Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, Daegu, South Korea

[2] Sejong Dementia Ctr, Sejong, South Korea

[3] Yonsei Univ, Dept Internal Med, Div Geriatr, Coll Med, Seoul, South Korea

[4] Sungkyunkwan Univ, Samsung Med Ctr, Dept Internal Med, Div Endocrinol & Metab,Sch Med, Seoul, South Korea

[5] Korea Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, Seoul, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2021年 / 36卷 / 27期

基金：

新加坡国家研究基金会;

关键词：

Continuous Glucose Monitoring; Glucose Variability; Time In Range; Frailty; Geriatrics; HYPERGLYCEMIA;

D O I：

10.3346/jkms.2021.36.e190

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the relationship between glucose variability and frailty. Forty-eight type 2 diabetic patients aged >= 65 years were enrolled. The FRAIL scale was used for frailty assessment, and participants were classified into 'healthy & pre-frail' (n = 24) and 'frail' (n = 24) groups. A continuous glucose monitoring (CGM) system was used for a mean of 6.9 days and standardized CGM metrics were analyzed: mean glucose, glucose management indicator (GMI), coefficient of variation, and time in range, time above range (TAR), and time below range. The demographics did not differ between groups. However, among the CGM metrics, mean glucose, GMI, and TAR in the postprandial periods were higher in the frail group (all P < 0.05). After multivariate adjustments, the post-lunch TAR (OR = 1.12, P = 0.019) affected the prevalence of frailty. Higher glucose variability with marked daytime postprandial hyperglycemia is significantly associated with frailty in older patients with diabetes.

引用

页数：6

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