Diverse effects of tumor necrosis factor-alpha on three subclones from human myelomonocytic leukemia cell line ME-1 exhibiting different differentiation stages

被引：2
作者：
Yanagisawa, K
Watanabe, I
Inoue, Y
Horiuchi, T
Hasegawa, H
Yasukawa, M
Fujita, S
机构：
[1] First Department of Internal Medicine, Ehime University, School of Medicine, Ehime
[2] First Department of Internal Medicine, School of Medicine, Ehime University, Ehime 791-02, Shigenobu
来源：
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 1996年 / 16卷 / 09期
关键词：
D O I：
10.1089/jir.1996.16.685
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of tumor necrosis factor-alpha (TNF-alpha) were examined in three subclone cells from human myelomonocytic leukemia cell line ME-1. These three subclone cells exhibit different differentiation stages of the myelomonocytic lineage. TNF-alpha exerted a growth-suppressive effect on the least mature subclone cells, ME-F-2 cells. On the other hand, TNF-alpha induced the most mature ME-F-1 cells and intermediate ME-F-3 cells to differentiate along the monocytic pathway. TNF-alpha also enhanced interferon-gamma (IFN-gamma)-induced complement C2 production by ME-F-1 and ME-F-3 cells but did not affect production by differentiated ME-F-1 and ME-F-3 cells. These results suggest that the diversity of the effects of TNF on subclone cells from ME-1 depends on the stage of cell differentiation.
引用
收藏
页码：685 / 693
页数：9
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