Olfactory Deficits in Normal Aging and Alzheimer's Disease in the Polish Elderly Population

被引：35

作者：

Makowska, Iwona ^{[2
]}

Kloszewska, Iwona ^{[2
]}

Grabowska, Anna ^{[1
,3
]}

Szatkowska, Iwona ^{[1
]}

Rymarczyk, Krystyna ^{[1
]}

机构：

[1] M Nencki Inst Expt Biol, Dept Neurophysiol, PL-02093 Warsaw, Poland

[2] Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Lodz, Poland

[3] Warsaw Sch Social Sci & Humanities, Dept Expt Neuropsychol, Warsaw, Poland

来源：

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY | 2011年 / 26卷 / 03期

关键词：

Alzheimer's disease; Olfaction; Cognitive enhancement; SMELL IDENTIFICATION TEST; ODOR IDENTIFICATION; PATHOLOGICAL-CHANGES; VASCULAR DEMENTIA; SEX-DIFFERENCES; SCREENING-TEST; DYSFUNCTION; MEMORY; AGE; PERFORMANCE;

D O I：

10.1093/arclin/acr011

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Alzheimer's disease (AD) is the most frequent cause of dementia. For this reason, a simple, reliable, and inexpensive method of early AD detection is urgently required. The location of neuropathological changes in AD patients indicates the potential diagnostic utility of olfactory tests. The purpose of this study was to compare odor identification performance among Polish subjects and to define the correlation between olfactory deficits and cognitive impairment. Olfactory identification performance was established in AD patients, and young and elderly healthy subjects using the Pocket Smell Test. AD Assessment Scale, the cognitive subscale, was used to evaluate cognitive functioning in the elderly participants. Compared with young subjects, the elderly individuals exhibited a diminished capacity to identify odors. AD patients also identified significantly fewer odors than healthy participants of the same age. In both the AD patients and the elderly control group, odor identification ability correlated with performance in cognitive tests. It may be concluded that deficits in olfactory identification occur in AD and may be valuable as an indicator of this condition.

引用

页码：270 / 279

页数：10

共 60 条

[1] Olfactory dysfunction as a predictor of neuro degenerative disease [J].

Albers, Mark W. ;

Tabert, Mattbias H. ;

Devanand, D. P. .

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2006, 6 (05) :379-386

[2] Cellular and molecular neuropathology of the olfactory epithelium and central olfactory pathways in Alzheimer's disease and schizophrenia [J].

Arnold, SE ;

Smutzer, GS ;

Trojanowski, JQ ;

Moberg, PJ .

OLFACTION AND TASTE XII: AN INTERNATIONAL SYMPOSIUM, 1998, 855 :762-775

[3]

Attems J, 2006, CLIN NEUROPATHOL, V25, P265

[4] Gender differences in dementia risk factors [J].

Azad, Nahid A. ;

Al Bugami, Muneerah ;

Loy-English, Inge .

GENDER MEDICINE, 2007, 4 (02) :120-129

[5] Sex differences in the clinical manifestations of Alzheimer disease pathology [J].

Barnes, LL ;

Wilson, RS ;

Bienias, JL ;

Schneider, JA ;

Evans, DA ;

Bennett, DA .

ARCHIVES OF GENERAL PSYCHIATRY, 2005, 62 (06) :685-691

[6] Sex differences in human olfaction: Between evidence and enigma [J].

Brand, G ;

Millot, JL .

QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 2001, 54 (03) :259-270

[7] DISTRIBUTION OF CEREBRAL DEGENERATION IN ALZHEIMERS-DISEASE - CLINICOPATHOLOGICAL STUDY [J].

BRUN, A ;

GUSTAFSON, L .

ARCHIV FUR PSYCHIATRIE UND NERVENKRANKHEITEN, 1976, 223 (01) :15-33

[8]

BUCHSBAUM MS, 1991, ARCH GEN PSYCHIAT, V48, P840

[9] FMRI brain activation in response to odors is reduced in primary olfactory areas of elderly subjects [J].

Cerf-Ducastel, B ;

Murphy, C .

BRAIN RESEARCH, 2003, 986 (1-2) :39-53

[10] Utility of olfactory identification test for diagnosing chinese patients with Alzheimer's disease [J].

Chan, A ;

Tam, J ;

Murphy, C ;

Chiu, H ;

Lam, L .

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2002, 24 (02) :251-259

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