Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B-cell lymphoma (SRPL)

被引：35

作者：

Baseggio, L. ^{[4
]}

Traverse-Glehen, A. ^{[2
,4
]}

Callet-Bauchu, E. ^{[4
]}

Morel, D. ^{[4
]}

Magaud, J. P. ^{[4
]}

Berger, F. ^{[2
,4
]}

Salles, G. ^{[3
,4
]}

Felman, P. ^{[1
,4
]}

机构：

[1] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Serv Hematol Biol, Lab Hematol Cellulaire, F-69495 Pierre Benite, France

[2] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Serv Anat Pathol, F-69495 Pierre Benite, France

[3] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Serv Hematol Clin, F-69495 Pierre Benite, France

[4] Univ Lyon 1, CNRS, Equipe Pathol Cellules Lymphoides, UMR 5239, F-69365 Lyon, France

来源：

HEMATOLOGICAL ONCOLOGY | 2011年 / 29卷 / 01期

关键词：

CD11c; hairy-cell variant; immunophenotype; splenic lymphoma with villous lymphocytes; splenic marginal zone lymphoma; splenic red pulp lymphoma with numerous basophilic villous lymphocytes; VILLOUS LYMPHOCYTES; DISORDERS; HAIRY;

D O I：

10.1002/hon.957

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

'Splenic red pulp lymphoma with numerous basophilic villous lymphocytes' (SRPL), recently described, is characterized by clinical, morphologic, immunologic, cytogenetic and molecular features distinct from SMZL/SLVL and HCL. In particular, the intensity of CD11c staining ( expressed as fluorescence intensity -RFI-) in SRPL is significantly different from the RFI in SMZL/SLVL and HCL. Moreover the use of a scoring system based on the expression of CD11c, CD22, CD76, CD38 and CD27 appears to improve the differential diagnosis between SRPL and SMZL/SLVL and emphasizes that SRPL is an entity closed to but distinct from SMZL/SLVL. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：47 / 51

页数：5

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