Iron-catalyzed cross-coupling reactions:: Efficient synthesis of 2,3-allenol derivatives

被引：143

作者：

Fürstner, A ^{[1
]}

Méndez, M ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 43期

关键词：

alkynes; allenes; cross-coupling; epoxides; iron;

D O I：

10.1002/anie.200352441

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reliable chirality transfer is one of the major advantages of a novel synthesis of 2,3-allenols from propargyl epoxides (see scheme) catalyzed by inexpensive and environmentally benign iron salts. The reactions proceed very rapidly in excellent yields and with moderate to good diastereoselectivity in favor of the syn-configured product.

引用

页码：5355 / 5357

页数：3

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