Background: An important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Although nearly all recent studies supported the existence of fragile regions in mammalian genomes, the most comprehensive phylogenomic study of mammals raised some doubts about their existence. Results: Here we demonstrate that fragile regions are subject to a birth and death process, implying that fragility has a limited evolutionary lifespan. Conclusions: This finding implies that fragile regions migrate to different locations in different mammals, explaining why there exist only a few chromosomal breakpoints shared between different lineages. The birth and death of fragile regions as a phenomenon reinforces the hypothesis that rearrangements are promoted by matching segmental duplications and suggests putative locations of the currently active fragile regions in the human genome.
机构:
Harvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Boston Univ, Bioinformat Program, Boston, MA 02215 USAHarvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Bhutkar, Arjun
;
Schaeffer, Stephen W.
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Penn State Univ, Dept Biol, University Pk, PA 16802 USA
Penn State Univ, Inst Mol Evolutionary Genet, University Pk, PA 16802 USAHarvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Schaeffer, Stephen W.
;
Russo, Susan M.
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机构:Harvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Russo, Susan M.
;
Xu, Mu
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机构:
Penn State Univ, Dept Biol, University Pk, PA 16802 USA
Penn State Univ, Inst Mol Evolutionary Genet, University Pk, PA 16802 USAHarvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Xu, Mu
;
Smith, Temple E.
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机构:
Boston Univ, Bioinformat Program, Boston, MA 02215 USAHarvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Smith, Temple E.
;
Gelbart, Wifflam M.
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机构:Harvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
机构:
Case Western Reserve Univ, Sch Med, Ctr Human Genet, Dept Genet, Cleveland, OH 44106 USACase Western Reserve Univ, Sch Med, Ctr Human Genet, Dept Genet, Cleveland, OH 44106 USA
Eichler, EE
;
Sankoff, D
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机构:Case Western Reserve Univ, Sch Med, Ctr Human Genet, Dept Genet, Cleveland, OH 44106 USA
机构:
Harvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Boston Univ, Bioinformat Program, Boston, MA 02215 USAHarvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Bhutkar, Arjun
;
Schaeffer, Stephen W.
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Biol, University Pk, PA 16802 USA
Penn State Univ, Inst Mol Evolutionary Genet, University Pk, PA 16802 USAHarvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Schaeffer, Stephen W.
;
Russo, Susan M.
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Russo, Susan M.
;
Xu, Mu
论文数: 0引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Biol, University Pk, PA 16802 USA
Penn State Univ, Inst Mol Evolutionary Genet, University Pk, PA 16802 USAHarvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Xu, Mu
;
Smith, Temple E.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Bioinformat Program, Boston, MA 02215 USAHarvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
Smith, Temple E.
;
Gelbart, Wifflam M.
论文数: 0引用数: 0
h-index: 0
机构:Harvard Univ, Dept Mol & Cellular Biol, Gelbart Lab, Cambridge, MA 02138 USA
机构:
Case Western Reserve Univ, Sch Med, Ctr Human Genet, Dept Genet, Cleveland, OH 44106 USACase Western Reserve Univ, Sch Med, Ctr Human Genet, Dept Genet, Cleveland, OH 44106 USA
Eichler, EE
;
Sankoff, D
论文数: 0引用数: 0
h-index: 0
机构:Case Western Reserve Univ, Sch Med, Ctr Human Genet, Dept Genet, Cleveland, OH 44106 USA