Comparative genomics reveals birth and death of fragile regions in mammalian evolution

被引:21
作者
Alekseyev, Max A. [1 ]
Pevzner, Pavel A. [2 ]
机构
[1] Univ S Carolina, Dept Comp Sci & Engn, Columbia, SC 29208 USA
[2] Univ Calif San Diego, Dept Comp Sci & Engn, La Jolla, CA 92093 USA
关键词
SEGMENTAL DUPLICATIONS REVEALS; MULTI-BREAK REARRANGEMENTS; MOUSE; SYNTENY; INVERSION; REUSE; RECOMBINATION; STABILITY; DYNAMICS; HOTSPOTS;
D O I
10.1186/gb-2010-11-11-r117
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background: An important question in genome evolution is whether there exist fragile regions (rearrangement hotspots) where chromosomal rearrangements are happening over and over again. Although nearly all recent studies supported the existence of fragile regions in mammalian genomes, the most comprehensive phylogenomic study of mammals raised some doubts about their existence. Results: Here we demonstrate that fragile regions are subject to a birth and death process, implying that fragility has a limited evolutionary lifespan. Conclusions: This finding implies that fragile regions migrate to different locations in different mammals, explaining why there exist only a few chromosomal breakpoints shared between different lineages. The birth and death of fragile regions as a phenomenon reinforces the hypothesis that rearrangements are promoted by matching segmental duplications and suggests putative locations of the currently active fragile regions in the human genome.
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页数:15
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