Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats

被引：42

作者：

Kocyigit, Umit M. ^{[1
]}

Taskiran, Ahmet Sevki ^{[2
]}

Taslimi, Parham ^{[3
]}

Yokus, Ahmet ^{[4
]}

Temel, Yusuf ^{[5
]}

Gulcin, Ilhami ^{[3
]}

机构：

[1] Cumhuriyet Univ, Vocat Sch Hlth Serv, TR-58140 Sivas, Turkey

[2] Cumhuriyet Univ, Dept Physiol, Fac Med, TR-58140 Sivas, Turkey

[3] Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey

[4] Cumhuriyet Univ, Vocat Sch Yldzeli, TR-58140 Sivas, Turkey

[5] Bingol Univ, Vocat Sch Solhan, TR-12000 Bingol, Turkey

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2017年 / 31卷 / 11期

关键词：

Enzyme activity; carbonic anhydrase; oxytocin; rat; IN-VITRO; II INHIBITION; PURIFICATION; VASOPRESSIN; PROFILES; ESTERASE; MUSCLE;

D O I：

10.1002/jbt.21972

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to investigate the effects of oxytocin (OT), atosiban, which is an OT receptor antagonist, and OT-atosiban chemicals injected to rats on the activities of carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes in liver and kidney tissues of rats. For this purpose, four different groups, each consisting of six rats (n=6), were formed (control group, OT administered group, atosiban administered group, and both OT and atosiban administered group). The rats were necropsied 60min after intraperitoneal injection of chemicals into the rats. Liver tissues of rats were extracted. CA and AChE enzyme activities were measured for each tissue by using hydratase, esterase, and acetylcholiniodide methods. Activity values for each enzyme obtained were statistically calculated.

引用

页数：7

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