Stem cell- and gene-based therapies as potential candidates in Alzheimer's therapy

被引：28

作者：

Hosseini, Seyede Atefe ^{[1
]}

Mohammadi, Rezvan ^{[1
]}

Noruzi, Somaye ^{[1
]}

Mohamadi, Yousef ^{[2
,3
]}

Azizian, Mitra ^{[4
]}

Mousavy, Seyed Mojta ^{[5
]}

Ghasemi, Faezeh ^{[6
]}

Hesari, AmirReza ^{[6
]}

Sahebkar, Amirhossein ^{[7
,8
]}

Salarinia, Reza ^{[1
]}

Aghdam, Arad Mobasher ^{[9
]}

Mirzaei, Hamed ^{[10
]}

机构：

[1] North Khorasan Univ Med Sci, Sch Med, Dept Med Biotechnol & Mol Sci, Bojnurd, Iran

[2] Univ Tehran Med Sci, Dept Anat, Fac Med, Tehran, Iran

[3] Ilam Univ Med Sci, Dept Anat, Fac Med, Ilam, Iran

[4] Shahid Beheshti Univ Med Sci, Dept Clin Biochem, Fac Med, Tehran, Iran

[5] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Neurosci, Tehran, Iran

[6] Arak Univ Med Sci, Dept Biotechnol, Fac Med, Arak, Iran

[7] Mashhad Univ Med Sci, Inst Pharmaceut Technol, Biotechnol Res Ctr, Mashhad, Iran

[8] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran

[9] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran

[10] Isfahan Univ Med Sci, Sch Adv Technol Med, Dept Biomat Tissue Engn & Nanotechnol, Esfahan, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2018年 / 119卷 / 11期

关键词：

Alzheimer's disease; exosome; gene therapy; microRNA; stem cell; therapy; MARROW STROMAL CELLS; SPINAL-CORD-INJURY; AMYLOID-BETA; MOUSE MODEL; ADENOASSOCIATED VIRUS; IMPROVE COGNITION; TRANSGENIC MODEL; IN-VITRO; DISEASE; MEMORY;

D O I：

10.1002/jcb.27202

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) isa progressive neurodegenerative disorder, which is associated with impairments of memory, thinking, language, and reasoning. Despite extensive research aiming at the treatment of AD, durable and complete remissions are rare. Hence, new therapeutic approaches are required. Among various therapeutic approaches, stem cells (ie, neural stem cells, mesenchymal stem cells, and embryonic stem cells) and delivery of protective genes such asencoding nerve growth factor, APOE, and glial cell-derived neurotrophic factor have generated promise in AD therapy. Here, we summarized a variety of effective therapeutic approaches (ie, stem cells, and genes) in AD therapy.

引用

页码：8723 / 8736

页数：14

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