Active and passive immunization against Acinetobacter baumannii using an inactivated whole cell vaccine

被引：117
作者：
McConnell, Michael J. [1 ]
Pachon, Jeronimo [1 ]
机构：
[1] Univ Seville, CSIC, Unit Infect Dis Microbiol & Prevent Med, Univ Hosp Virgen del Rocio,Inst Biomed Sevilla IB, Seville 41013, Spain
来源：
VACCINE | 2010年 / 29卷 / 01期
关键词：
Acinetobacter baumannii; Vaccine; Passive immunization; RESISTANT ACINETOBACTER; INFECTION;
D O I：
10.1016/j.vaccine.2010.10.052
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The treatment of infections caused by Acinetobacter baumannii has become increasingly complicated due to the emergence of highly resistant strains. In the present study we demonstrate that immunization with an inactivated whole cell vaccine elicits a robust antibody response that provides protection against challenge with multiple A. baumannii strains in a murine model of disseminated sepsis. In addition, we show that passive immunization with serum raised against inactivated cells protects mice from subsequent infection. These results demonstrate that active and passive immunization using an inactivated whole cell vaccine may be an effective approach for preventing infection by A. baumannii. (C) 2010 Elsevier Ltd. All rights reserved.
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页码：1 / 5
页数：5
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