Synthesis of 5-spiro (5′-methylisatin)-4-acetyl-2-(acetylamino)-Δ2-1,3,4-thiadiazoline and 5-spiro(5′-methylisatin)-4-acetyl-2-(5′-methylisatin-3′-hydrazino)-Δ2-1,3,4-thiadiazoline

被引：0

作者：

Islam, R ^{[1
]}

Abedin, MJ ^{[1
]}

Khayer, K ^{[1
]}

Islam, MR ^{[1
]}

机构：

[1] Jahangirnagar Univ, Dept Chem, Dhaka, Bangladesh

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2001年 / 40卷 / 03期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of 5-methylisatin 1 with thiosemicarbazide in glacial acetic acid gives 5-methylisatin-3-thiosemicarbazone 2, whereas with thiocarbohydrazide gives bis-5-methylisatin-3-thiocarbohydrazone 3. Acetylation of 2 and 3 with acetic anhydride affords 5-spiro (5'-methylisatin)-4-acetyl-2-(acetylamino)-Delta (2)-1,3,4-thiadiazoline 4 and 5-spiro(5'-methylisatin)-4-acetyl-2-(5'-methylisatin-3'-hydrazino)-Delta (2)-1,3,4-thiadiazoline 5 hydride furnishes 1,1'-N,N-dimethylated product 6.

引用

页码：240 / 242

页数：3

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