What can we learn about amphiphile-membrane interaction from model lipid membranes?

被引：13

作者：

Fanani, Maria Laura ^{[1
,2
]}

Nocelli, Natalia E. ^{[1
,2
]}

Zulueta Diaz, Yenisleidy de las Mercedes ^{[1
,2
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Quim Biol Ranwel Caputto, Cordoba, Argentina

[2] Ctr Invest Quim Biol Cordoba CIQUIBIC, CONICET, Cordoba, Argentina

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2022年 / 1864卷 / 01期

关键词：

Amphiphilic drugs; Langmuir films; Miltefosine; Brewster angle microscopy; Ascorbyl palmitate; STRATUM-CORNEUM LIPIDS; AMPHOTERICIN-B; LANGMUIR MONOLAYERS; PHASE-BEHAVIOR; PHOSPHOLIPID-MEMBRANES; MOLECULAR-INTERACTIONS; BIOACTIVE MOLECULES; SKIN BARRIER; ACYL-CHAIN; CHOLESTEROL;

D O I：

10.1016/j.bbamem.2021.183781

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Surface-active amphiphiles find applications in a wide range of areas of industry such as agrochemicals, personal care, and pharmaceuticals. In many of these applications, interaction with cell membranes is a key factor for achieving their purpose. How do amphiphiles interact with lipid membranes? What are their bases for membrane specificity? Which biophysical properties of membranes are susceptible to modulation by amphiphilic membrane-effectors? What aspects of this interaction are important for performing their function? In our work on membrane biophysics over the years, questions like these have arisen and we now share some of our findings and discuss them in this review. This topic was approached focusing on the membrane properties and their alterations rather than on the amphiphile structure requirements for their interaction. Here, we do not aim to provide a comprehensive list of the modes of action of amphiphiles of biological interest but to help in understanding them.

引用

页数：11

共 117 条

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