Association between BDNF Val66Met genotype and episodic memory

被引：150

作者：

Dempster, E ^{[1
]}

Toulopoulou, T ^{[1
]}

McDonald, C ^{[1
]}

Bramon, E ^{[1
]}

Walshe, M ^{[1
]}

Filbey, F ^{[1
]}

Wickham, H ^{[1
]}

Sham, PC ^{[1
]}

Murray, RM ^{[1
]}

Collier, DA ^{[1
]}

机构：

[1] Inst Psychiat, Mol Genet Sect, Div Psychol Med, London SE5 8AF, England

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2005年 / 134B卷 / 01期

关键词：

D O I：

10.1002/ajmg.b.30150

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The val(66) met polymorphism of brain derived neurotrophic factor (BDNF) has been associated with variability in episodic memory [Egan et al., 2003]. In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val(66) met polymorphism. We analyzed the effect of this polymorphism on episodic memory using the Wechsler Memory Scale, revised version (WMS-R) by regression analysis between the WMS delayed score of logical memory and genotype (corrected for age, sex, and IQ). We found the met(66) allele conferred a lower score on the WMS delayed measure (R-2=0.014 P=0.09), which was not significant. When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R-2=0.077 P=0.01), which is consistent with previous findings. C 2005 Wiley-Liss, Inc.

引用

页码：73 / 75

页数：3

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